特定神经元群体中电活动的精确调节对于纠正异常的神经功能至关重要,并且是治疗神经系统疾病的关键要素。然而,在最小的侵袭性和强大的神经保护之间取得平衡是一个相当大的挑战。在这里,我们提出了一种整合神经保护功能的纳米神经调节策略,以最小的侵袭性有效治疗癫痫,并实现无线功能.战略设计的纳米传感器,用二硫化钛(TiS2)(TiS2/Pt)装饰铂(Pt)装饰,能够在体外和体内精确调节神经元电活动,在毫秒精度的近红外(NIR)光脉冲照射下确保出色的时间保真度。同时,TiS2/Pt表现出明显的酶模拟活性增强,在体外提供对氧化性神经损伤的强大防御。具有生物催化神经保护能力的纳米换能器无线神经调节在缓解癫痫性高频神经活动和降低氧化应激水平方面非常有效,从而恢复氧化还原平衡。这种综合治疗方法降低了癫痫的严重程度,展示最小的侵入性和消除基因操作和光纤植入的要求,同时为神经系统疾病的治疗提供了另一种途径。
The precise modulation of electrical activity in specific neuronal populations is paramount for rectifying abnormal neurological functions and is a critical element in the therapeutic arsenal for neurological disorders. However, achieving a balance between minimal invasiveness and robust neuroprotection poses a considerable challenge. Herein, we present a nanoneuromodulation strategy integrating neuroprotective features to effectively address epilepsy with minimal invasiveness and enable wireless functionality. Strategically engineered
nanotransducer, adorned with platinum (Pt) decoration with titanium disulfide (TiS2) (TiS2/Pt), enables precise modulation of neuronal electrical activity in vitro and in vivo, ensuring exceptional temporal fidelity under millisecond-precision near-infrared (NIR) light pulses irradiation. Concurrently, TiS2/Pt showcase a pronounced enhancement in enzyme-mimicking activity, offering a robust defense against oxidative neurological injury in vitro.
Nanotransducer-enabled wireless neuromodulation with biocatalytic neuroprotective capacity is highly effective in alleviating epileptic high-frequency neural activity and diminishing oxidative stress levels, thereby restoring redox equilibrium. This integrated therapeutic approach reduces the severity of epilepsy, demonstrating minimal invasiveness and obviating the requirements for genetic manipulation and optical fiber implantation, while providing an alternative avenue for neurological disorder treatment.