背景:对硬软组织状况的评估是整个牙科治疗的一部分。
目的:在本研究中,作为一项临床试验研究,我们研究了含有纳米姜黄素的膜,以改善拔牙区硬软组织的质量.
方法:按照纳入和排除标准选择患者后,在介入治疗的一侧,从口腔两侧(裂口)拔牙的患者接受了含有纳米姜黄素的膜,在控制方面,没有材料被放置在插座。对于数据分析,使用SPSS软件版本24。显著性阈值被认为在概率方面小于0.05。
结果:拔牙后两个月,在植入物放置期间,干预侧的平均牙龈厚度,“为3.1±0.34毫米,而“对照侧”的平均牙龈厚度为2.6±0.42毫米。然后,膜可以改善软组织质量(P<0.0001)。作为另一个结果,与对照组相比,应用此膜对这些患者的骨修复没有显著影响(P=0.72).然而,组织学数据显示,干预组的新生成的骨靠近膜,证明了膜的骨传导能力。
结论:根据获得的结果,新开发的膜可用于改善拔牙区硬软组织的质量。尽管如此,在未来的研究中,硬组织再生需要更多的努力来调整纳米姜黄素的剂量.
BACKGROUND: The assessment of the hard and soft tissue conditions is part of the overall dental treatments.
OBJECTIVE: In this study, we investigated nano curcumin-containing membranes to improve the quality of the hard and soft tissues in the extracted tooth area as a clinical trial study.
METHODS: After the patient was selected following the inclusion and exclusion criteria, the patients who had teeth extracted from both sides of the mouth (split mouth) on the side of the intervention received a membrane containing
nanocurcumin, and on the control side, no material was placed in the socket. For data analysis, SPSS software version 24 was used. A significance threshold was deemed to be less than 0.05 in terms of probability.
RESULTS: Two months after tooth extraction, during implant placement, the average gingival thickness on the \"intervention side,\" was 3.1±0.34 mm, while the average gingival thickness on the \"control side\" was 2.6±0.42 mm. Then, the membrane could improve the quality of soft tissue (P< 0.0001). As another outcome, the application of this membrane did not significantly affect bone repair in these patients compared to the control group (P = 0.72). However, the histology data revealed that the newly generated bone of the intervention group was seen close to the membrane, demonstrating the osteoconductive ability of the membrane.
CONCLUSIONS: Based on the obtained results, the newly developed membrane can be used to improve the quality of hard and soft tissues in the extracted tooth area. Nonetheless, more efforts in
nanocurcumin dosage adjustment are needed for hard tissue regeneration in future studies.