PDF(Pubmed)
Abstract：
The objective of this study is the development of innovative nanocurcumin-based formulations designed for the treatment and prevention of oxidative stress and diabetes. Nanocurcumin was obtained through a micronization process and subsequently encapsulated within biopolymers derived from corn starch and fenugreek mucilage, achieving encapsulation rates of 75% and 85%, respectively. Subsequently, the encapsulated nanocurcumin was utilized in the formulation of sugar-free syrups based on Stevia rebaudiana Bertoni. The stability of the resulting formulations was assessed by monitoring particle size distribution and zeta potential over a 25-day period. Dynamic light scattering (DLS) revealed a particle size of 119.9 nm for the fenugreek mucilage-based syrup (CURF) and 117 nm for the corn starch-based syrup (CURA), with polydispersity indices PDIs of 0.509 and 0.495, respectively. The dissolution rates of the encapsulated nanocurcumin were significantly enhanced, showing a 67% improvement in CURA and a 70% enhancement in CURF compared with crude curcumin (12.82%). Both formulations demonstrated excellent antioxidant activity, as evidenced by polyphenol quantification using the 2.2-diphenyl 1-pycrilhydrazyl (DPPH) assay. In the evaluation of antidiabetic activity conducted on Wistar rats, a substantial reduction in fasting blood sugar levels from 392 to 187 mg/mL was observed. The antioxidant properties of CURF in reducing oxidative stress were clearly demonstrated by a macroscopic observation of the rats\' livers, including their color and appearance.
摘要：
这项研究的目的是开发创新的基于纳米姜黄素的配方，旨在治疗和预防氧化应激和糖尿病。通过微粉化过程获得纳米姜黄素，随后将其封装在源自玉米淀粉和胡芦巴粘液的生物聚合物中，达到75%和85%的包封率，分别。随后，包封的纳米姜黄素用于基于甜叶菊的无糖糖浆的配方。通过在25天的时间内监测粒度分布和ζ电位来评估所得制剂的稳定性。动态光散射（DLS）显示，胡芦巴粘液基糖浆（CURF）的粒径为119.9nm，玉米淀粉基糖浆（CURA）的粒径为117nm。多分散指数PDIs分别为0.509和0.495。包封的纳米姜黄素的溶解速率显着提高，与粗姜黄素（12.82%）相比，CURA提高了67%，CURF提高了70%。两种配方都表现出优异的抗氧化活性，如使用2.2-二苯基1-吡喃肼基（DPPH）测定法的多酚定量所证明的。在对Wistar大鼠进行的抗糖尿病活性评估中，观察到空腹血糖水平从392mg/mL显著降低至187mg/mL.通过对大鼠肝脏的宏观观察清楚地证明了CRF在减少氧化应激方面的抗氧化特性，包括颜色和外观。
