背景:多项流行病学研究认为睡眠质量与口腔疾病风险之间存在潜在关联,然而由此得出的结论仍然有争议,因果关系的存在仍然模棱两可。在这项研究中,我们的目的是调查睡眠时间之间的因果关系,失眠,和常见的口腔疾病。
方法:我们利用遗传相关性和双样本孟德尔随机化分析,基于全基因组睡眠时间关联研究的汇总统计(N=460,099),失眠(N=462,341),口腔溃疡(N=385,026),口腔癌(N=4,151),和牙周病(N=527,652)。
结果:我们的结果显示睡眠时间与口腔溃疡之间存在负遗传相关性(遗传相关性:-0.09,P=0.007),同时观察到失眠和口腔溃疡之间的遗传正相关(遗传相关性:0.18,P=2.51E-06)。此外,我们证实睡眠时间延长与口腔溃疡风险降低显著相关(OR:0.67,95%CI:0.54-0.83,P=2.84E-04),而失眠名义上与口腔溃疡风险增加相关(OR:1.40,95%CI:1.01-1.95,P=0.044).相比之下,未检测到睡眠质量与牙周病或口腔癌之间存在显著关联.
结论:这项工作提供了有力的证据来支持以下观点:提高睡眠质量可以降低口腔溃疡的风险,从而具有相当大的临床相关性。
Multiple epidemiological studies have posited a potential association between sleep quality and the risk of oral diseases, yet the resulting conclusions have remained contentious, and the presence of a causal link remains equivocal. In this study, we aimed to investigate the causal relationship between sleep duration, insomnia, and common oral diseases.
We utilized genetic correlation and two-sample Mendelian randomization analyses based on summary statistics from genome-wide association studies of sleep duration (N = 460,099), insomnia (N = 462,341), mouth ulcer (N = 385,026), oral cavity cancer (N = 4,151), and periodontal disease (N = 527,652).
Our results revealed a negative genetic correlation between sleep duration and mouth ulcer (genetic correlation: -0.09, P = 0.007), while a positive genetic correlation between insomnia and mouth ulcer was observed (genetic correlation: 0.18, P = 2.51E-06). Furthermore, we demonstrated that longer sleep duration is significantly associated with a reduced risk of mouth ulcers (OR: 0.67, 95% CI: 0.54-0.83, P = 2.84E-04), whereas insomnia is nominally associated with an increased risk of mouth ulcers (OR: 1.40, 95% CI: 1.01-1.95, P = 0.044). In contrast, no significant association was detected between sleep quality and periodontal disease or oral cavity cancer.
This work provides robust evidence to support the notion that enhanced sleep quality may confer a decreased risk of oral ulcers, thereby bearing considerable clinical relevance.