颅面纤维骨病变(CFOL)是一组相对罕见的实体,其病因从反应性到发育不良,有可能发生恶性转化。它的特点是用纤维组织代替骨骼,随后发展不同程度的钙化。纤维发育不良(FD)是纤维骨病变谱的组成部分。FD的临床范围很广,从影响单个骨骼的轻微单骨病变到涉及整个骨骼的破坏性多骨疾病。FD产生不对称性,这损害了面部美学。FD导致骨分化,解体,和混乱。它描绘了缺乏有丝分裂图和多态性的细胞胶原基质。毛细血管分布均匀,编织骨或板层骨的细长小梁具有不均匀的曲线(通常称为汉字图案)。通过计算机断层扫描(CT)成像可以识别三种类型的FD模式:囊状模式,均匀致密的图案,和磨砂玻璃图案。治疗的基石是手术,尽管方法因位置而异,尺寸,和病变的症状。作为手术的替代方案,正在考虑使用双膦酸盐来降低破骨细胞活性。在这个系列中,我们介绍了3例累及上颌骨和下颌骨的FD。我们的目标是联系临床表现,组织学特征,和射线照相结果,促进早期诊断,治疗,患者预后较好。
Craniofacial fibro-osseous lesions (CFOLs) are a diverse group of relatively rare entities whose etiology ranges from reactive to dysplastic with a potential for malignant transformation. It is distinguished by the replacement of bone with fibrous tissue, that subsequently develops different degrees of calcification. Fibrous dysplasia (FD) is a component of the fibro-osseous lesion spectrum. The clinical spectrum of FD is wide, ranging from minor
monostotic lesions affecting a single bone to devastating polyostotic disease involving the entire skeleton. FD produces asymmetry, which impairs face aesthetics. FD leads to bone differentiation, disintegration, and disorganization. It depicts a cellular collagenous stroma lacking mitotic figures and pleomorphism. Blood capillaries are evenly distributed, as are elongated trabeculae of woven or lamellar bone with uneven curves (often referred to as the Chinese letters pattern). Three types of FD patterns can be identified by computed tomography (CT) imaging: a cystic pattern, a homogeneously dense pattern, and a ground-glass pattern. The cornerstone of treatment is surgery, although the method varies depending on the location, size, and symptoms of the lesion. As an alternative to surgery, the use of bisphosphonates to reduce osteoclastic activity is under consideration. In this case series, we present three cases of FD involving the maxilla and mandible. We aim to correlate the clinical presentation, histological features, and radiographic findings, to promote early diagnosis, treatment, and better prognosis of the patient.