背景:在当前的系统评价和荟萃分析中,我们旨在分析现有文献以评估炎症生物标志物的作用,包括中性粒细胞与淋巴细胞比率(NLR),血小板与淋巴细胞比率(PLR),C反应蛋白(CRP),肿瘤坏死因子-a(TNF-a),与健康对照组相比,患有心脏综合征X(CSX)的个体中的白细胞介素-6(IL-6)。
方法:我们使用PubMed,WebofScience,Scopus,科学直接,和Embase系统地搜索2023年4月2日之前出版的相关出版物。我们使用Stata11.2软件进行了荟萃分析(StataCorp,学院站,TX)。所以,我们使用标准平均差(SMD)和95%置信区间(CI)来比较患者和健康对照组之间的生物标志物水平.采用I2和Cochran'sQ检验确定纳入研究的异质性。
结果:总体而言,分析中纳入了29篇文章,3480名参与者(1855名CSX和1625名健康对照)。NLR水平明显较高(SMD=0.85,95CI=0.55-1.15,I2=89.0%),CRP(SMD=0.69,95CI=0.38至1.02,p<0.0001),IL-6(SMD=5.70,95CI=1.91至9.50,p=0.003),TNF-a(SMD=3.78,95CI=0.63至6.92,p=0.019),与健康对照组相比,CSX组的PLR(SMD=1.38,95CI=0.50至2.28,p=0.02)。
结论:这项研究的结果表明,CSX导致炎症生物标志物的显着增加,包括NLR,CRP,IL-6,TNF-a,和PLR。
BACKGROUND: In the current systematic review and meta-analysis, we aim to analyze the existing literature to evaluate the role of inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP), tumor necrosis factor-a (TNF-a), and interleukin-6 (IL-6) among individuals with cardiac syndrome X (CSX) compared to healthy controls.
METHODS: We used PubMed, Web of Science, Scopus, Science Direct, and Embase to systematically search relevant publications published before April 2, 2023. We performed the meta-analysis using Stata 11.2 software (Stata Corp, College Station, TX). So, we used standardized mean difference (SMD) with a 95% confidence interval (CI) to compare the biomarker level between patients and healthy controls. The I2 and Cochran\'s Q tests were adopted to determine the heterogeneity of the included studies.
RESULTS: Overall, 29 articles with 3480 participants (1855 with CSX and 1625 healthy controls) were included in the analysis. There was a significantly higher level of NLR (SMD = 0.85, 95%CI = 0.55-1.15, I2 = 89.0 %), CRP (SMD = 0.69, 95%CI = 0.38 to 1.02, p < 0.0001), IL-6 (SMD = 5.70, 95%CI = 1.91 to 9.50, p = 0.003), TNF-a (SMD = 3.78, 95%CI = 0.63 to 6.92, p = 0.019), and PLR (SMD = 1.38, 95%CI = 0.50 to 2.28, p = 0.02) in the CSX group in comparison with healthy controls.
CONCLUSIONS: The results of this study showed that CSX leads to a significant increase in inflammatory biomarkers, including NLR, CRP, IL-6, TNF-a, and PLR.