背景:雄激素剥夺治疗是男性晚期前列腺癌的常用治疗方法。他们经历了许多复杂的症状,影响他们的生活质量。然而,缺乏综合前列腺癌男性症状经历的定性评论。
目的:探讨男性在前列腺癌雄激素剥夺治疗中的症状体验。
方法:使用meta聚集的定性证据合成。
方法:2001年1月至2023年8月之间的已发表和未发表的文献来自PubMed,Embase(Ovid),WebofScience,护理和相关健康文献累积指数(CINAHL),科克伦图书馆,ProQuest,谷歌学者,中国国家知识基础设施(CNKI),王芳,和VIP。
方法:两名评审员独立进行筛选,研究选择和数据提取,并使用JoannaBriggs研究所的定性研究关键评估清单进行质量评估。使用元聚合方法进行数据合成。
结果:包括24篇中等至高方法学质量的文章。总共提取了98个发现,其中59个明确或模棱两可的发现符合元聚合条件,分为九类,并发展了四个综合发现:(1)症状的产生:未识别和低估,(2)对症状的感知:多样而复杂,(3)症状的含义:威胁和影响,(4)对症状的反应:推拉。
结论:男性在前列腺癌的整个雄激素剥夺过程中经历了四个危机期。医疗保健提供者需要了解男性的想法,无论是在共同决策的过程中还是在选择的治疗过程中。未来的研究应该开发适合个体的干预措施,并提供管理症状的实用策略。PROSPERO注册:CRD42023449129。
BACKGROUND: Androgen deprivation therapy is a common treatment for men with advanced prostate cancer. They have experienced many complex symptoms that affect their quality of life. However, qualitative reviews that synthesize the symptom experience for men with prostate cancer are lacking.
OBJECTIVE: To explore the men\'s symptom experience throughout androgen deprivation therapy for prostate cancer.
METHODS: A qualitative evidence synthesis using meta-aggregation.
METHODS: Published and unpublished literature between January 2001 and August 2023 were identified from PubMed, Embase (Ovid), Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), The Cochrane Library, ProQuest, Google Scholar, China National Knowledge Infrastructure (CNKI), Wang Fang, and VIP.
METHODS: Two reviewers independently conducted screening, study selection and data extraction, and quality appraisal was performed using the Joanna Briggs Institutes Critical Appraisal Checklist for Qualitative Research. Data synthesis was conducted using meta-aggregative approach.
RESULTS: 24 articles of moderate to high methodological quality were included. A total of 98 findings were extracted with 59 unequivocal or equivocal findings eligible for meta-aggregation, aggregated into nine categories, and developed four synthesized findings: (1) production of symptoms: unrecognized and underestimated, (2) perception of symptoms: varied and complicated, (3) meaning of symptoms: threatened and affected, and (4) response to symptoms: push and pull.
CONCLUSIONS: Men throughout androgen deprivation for prostate cancer experience the four crisis-packed stages in their symptomatic journey. Health care provider need to understand the men\'s thoughts whether in the process of shared decision-making or in the course of the chosen therapy. Future research should develop individual suitable interventions and offer practical strategies for managing symptom. PROSPERO registration: CRD42023449129.