■精神障碍患者心血管事件的风险增加。我们的目的是评估过去二十年来美国精神和行为合并症患者的心血管死亡率趋势。
■我们进行了回顾性研究,使用疾病控制和预防中心广泛的流行病学研究在线数据(CDCWONDER)多死因数据集的观察性研究。我们确定了有和没有精神和行为障碍的患者中归因于心血管疾病的年龄标准化死亡率的国家趋势,从1999年到2020年,按精神和行为障碍亚型[ICD10代码F]分层,年龄,性别,种族,和居住地。
■在美国超过1870万例心血管死亡中,13.5%[253万]患者伴有精神和行为障碍。在学习期间,在精神和行为障碍患者中,无精神障碍患者的年龄校正死亡率增加了113.9%,下降了44.8%(均P<0.05).在精神和行为障碍患者中,在精神和行为障碍继发于药物滥用的患者中,年龄调整后的死亡率增加更显著(+532.6%,p<0.05)高于器质性精神障碍患者,如痴呆或谵妄(+6.2%,P-不显著)。男性患者(163.6%)和更多农村地区的居民(128-162%)经历了年龄调整后的心血管死亡率的显着增加。
■尽管在过去的二十年中,美国的心血管死亡率总体上有所下降,我们证实,精神障碍患者的心血管死亡率总体上升.
UNASSIGNED: Patients with mental disorders are at increased risk of cardiovascular events. We aimed to assess the cardiovascular mortality trends over the last two decades among patients with mental and behavioral co-morbidities in the US.
UNASSIGNED: We performed a retrospective, observational study using the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) Multiple Cause of Death dataset. We determined national trends in age-standardized mortality rates attributed to cardiovascular diseases in patients with and without mental and behavioral disorders, from 1999 to 2020, stratified by mental and behavioral disorders subtype [ICD10 codes F], age, gender, race, and place of residence.
UNASSIGNED: Among more than 18.7 million cardiovascular deaths in the United States (US), 13.5% [2.53 million] were patients with a concomitant mental and behavioral disorder. During the study period, among patients with mental and behavioral disorders, the age-adjusted mortality rate increased by 113.9% Vs a 44.8% decline in patients with no mental disorder (both p<0.05). In patients with mental and behavioral disorders, the age-adjusted mortality rate increased more significantly among patients whose mental and behavioral disorder was secondary to substance abuse (+532.6%, p<0.05) than among those with organic mental disorders, such as dementia or delirium (+6.2%, P- nonsignificant). Male patients (+163.6%) and residents of more rural areas (+128-162%) experienced a more prominent increase in age-adjusted cardiovascular mortality.
UNASSIGNED: While there was an overall reduction in cardiovascular mortality in the US in the past two decades, we demonstrated an overall increase in cardiovascular mortality among patients with mental disorders.