未经评估:除了传统的心血管危险因素,性别特异性因素也可能导致颅内动脉粥样硬化.本研究旨在全面探讨无症状颅内动脉粥样硬化(aICAS)与月经或生殖史(MRH)的关系。即,月经,怀孕,分娩,更年期,和避孕。
UNASSIGNED:本研究的参与者选自孔村镇aICAS研究。MRH是通过结构化病例报告表收集的,在哪个初潮年龄,月经规律,痛经,怀孕次数,分娩数量,第一次怀孕的年龄,母乳喂养,更年期,更年期年龄,和避孕方法都涉及。所有特征均通过卡方检验和适用的非参数检验进行比较。采用Logistic回归模型和敏感性分析分析aICAS与MRH的相关性。
UNASSIGNED:共有1,052名女性参与者参与了这项研究,其中5.7%患有中度至重度aICAS。在单变量分析[粗比值比(OR)中,输卵管结扎与aICAS显着相关,2.85;95%CI,1.22-6.62;P=0.015]。在多变量调整后的60岁以上的女性参与者中,这种关联仍然显着(调整后的OR,4.36;95%CI,1.55-12.24;P=0.005)。敏感性分析显示类似的结果(调整后的OR,3.76;95%CI,1.24-11.41;P=0.020)。多变量调整后,更年期与aICAS失去了显著关联(调整后的OR,1.68;95%CI,0.66-4.24;P=0.275)。没有发现其他MRH因子与aICAS相关。
UNASSIGNED:输卵管结扎术可能与中国老年女性aICAS患病率较高有关。这为研究ICAS的流行病学特征提供了新的视角。
UNASSIGNED: In addition to traditional cardiovascular risk factors, gender-specific factors may also contribute to intracranial atherosclerosis. This study aimed to comprehensively investigate the association between asymptomatic intracranial atherosclerosis (aICAS) and menstrual or reproductive history (MRH), namely, menstruation, pregnancy, childbirth, menopause, and contraception.
UNASSIGNED: Participants in this study were selected from the Kongcun town aICAS study. MRH was collected through structured case report forms, in which menarche age, menstrual regularity, dysmenorrhea, number of pregnancies, number of childbirths, age of first pregnancy, breastfeeding, menopause, menopause age, and contraceptive methods were all involved. All characteristics were compared by chi-squared and nonparametric tests as applicable. Logistic regression model and sensitivity analysis were used to analyze the association between aICAS and MRH.
UNASSIGNED: A total of 1,052 female participants were involved in this study, of which 5.7% had moderate to severe aICAS. Tubal ligation was significantly associated with aICAS in univariate analysis [crude odds ratio (OR), 2.85; 95% CI, 1.22-6.62; P = 0.015]. This association was still significant among female participants over 60 years old after multivariate adjustment (adjusted OR, 4.36; 95% CI, 1.55-12.24; P = 0.005). Sensitivity analysis showed a similar result (adjusted OR, 3.76; 95% CI, 1.24-11.41; P = 0.020). Menopause lost significant association with aICAS after multivariate adjustment (adjusted OR, 1.68; 95% CI, 0.66-4.24; P = 0.275). No other MRH factors were found to be associated with aICAS.
UNASSIGNED: Tubal ligation may be associated with a higher prevalence of aICAS in Chinese elderly women. This provides a new perspective to study the epidemiological characteristics of ICAS.