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Abstract：
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is a recently described neuropathological construct associated with dementia. This study aimed to investigate in an autopsy study, LATE-NC and its associations with potential estrogen-related risk factors collected about 30 years before death. Participants were part of The 90+ Study and had, as part of the Leisure World Cohort Study, provided information on menstrual and reproductive variables and details of use of estrogen replacement therapy (ERT). No menstrual and reproductive variable showed an association with LATE-NC. Use of ERT, especially long-term use (15+ years) and more recent use (within 1 year of completing the questionnaire), was associated with reduced risk. The odds were significantly lower for long-term (0.39, 95% confidence interval [CI]: 0.16-0.95) and recent use (0.39, 95% CI: 0.16-0.91) compared with no use. In conclusion, we found that women who reported long-term ERT in their 50s and 60s had a significantly reduced odds of harboring LATE-NC when they died in the 10th and 11th decades of their lives. Our study adds to the existing literature reporting seemingly protective effect of peri- and postmenopausal ERT against neurodegenerative dementia.
摘要：
边缘占优势的年龄相关TDP-43脑病神经病理变化（LATE-NC）是最近描述的与痴呆相关的神经病理学结构。这项研究旨在调查尸检研究，死亡前约30年收集的LATE-NC及其与潜在雌激素相关危险因素的关联。参与者是90+研究的一部分，作为休闲世界队列研究的一部分，提供了有关月经和生殖变量的信息，以及使用雌激素替代疗法（ERT）的详细信息。没有月经和生殖变量显示与LATE-NC相关。使用ERT,特别是长期使用（15年以上）和最近使用（填写问卷后1年内），与风险降低有关。与不使用相比，长期（0.39，95％置信区间[CI]：0.16-0.95）和最近使用（0.39，95％CI：0.16-0.91）的几率显着降低。总之,我们发现,在50多岁和60多岁时报告长期ERT的女性在10岁和11岁时死亡时,其携带LATE-NC的几率显著降低.我们的研究增加了现有文献报道的绝经前后ERT对神经退行性痴呆的保护作用。
