■一些可疑为黑色素瘤的黑素细胞肿瘤需要额外的检查以达到最终诊断。在过去的八年里,基因表达谱(GEP)已成为辅助诊断恶性潜能不确定的黑色素细胞肿瘤的重要辅助工具.随着两种市售测试(23-GEP和35-GEP)的使用发展,重要的是要回答有关最佳利用及其对患者护理的影响的关键问题。
■评论中包含回答以下问题的最新和相关文章。首先,皮肤科医生如何综合现有文献,最新的指导方针,以及他们的临床经验,以确定哪些病例最有可能从GEP测试中受益?第二,皮肤科医生如何最好地向他们的皮肤病理学家传达,在诊断过程中使用GEP可以提供更明确定义的结果,从而帮助皮肤科医生在为其他病理模糊的病变做出具体的患者管理决策时提供更高质量的患者护理?
■当在临床上下文中解释时,病理性,和实验室信息,GEP结果可以方便及时的渲染,准确,并明确诊断黑素细胞病变,否则不确定的恶性潜力,以告知个性化的治疗和管理计划。
■这是一项叙述性综述,重点是GEP的临床应用,与活检后进行的其他辅助诊断测试相比。
■皮肤病理学家和皮肤科医生之间的开放沟通,特别是关于GEP测试,对于其他模糊的黑素细胞病变,可能是实现适当临床病理相关性的重要组成部分。
UNASSIGNED: Some melanocytic neoplasms suspicious for melanoma require additional workup to arrive at a final diagnosis. Within the last eight years, gene expression profiling (GEP) has become an important ancillary tool to aid in the diagnosis of melanocytic neoplasms with uncertain malignant potential. As the usage of two commercially available tests (23-GEP and 35-GEP) evolves, it is important to answer key questions about optimal utilization and their impact on patient care.
UNASSIGNED: Recent and relevant articles answering the following questions were included in the review. First, how do dermatopathologists synthesize the available literature, the latest guidelines, and their clinical experience to determine which cases would be most likely to benefit from GEP testing? Second, how best can a dermatologist convey to their dermatopathologist that the use of GEP in the diagnostic process could provide a more clearly defined result and thereby help empower the dermatologist to provide higher-quality patient care when making specific patient management decisions for otherwise pathologically ambiguous lesions?
UNASSIGNED: When interpreted in the context of the clinical, pathologic, and laboratory information, GEP results can facilitate the rendering of timely, accurate, and definitive diagnoses for melanocytic lesions with otherwise uncertain malignant potential to inform personalized treatment and management plans.
UNASSIGNED: This was a narrative review focused on clinical use of GEP compared to other ancillary diagnostic tests performed postbiopsy.
UNASSIGNED: Open communication between dermatopathologists and dermatologists, especially regarding GEP testing, can be a vital component to achieve appropriate clinicopathologic correlation for otherwise ambiguous melanocytic lesions.