PDF(Pubmed)
Abstract：
Aim: Cutaneous melanocytic neoplasms with diagnostic and/or clinical ambiguity pose patient management challenges. Methods: Six randomized case scenarios with diagnostic/clinical uncertainty were described with/without a benign or malignant diagnostic gene expression profile (GEP) result. Results: Clinical impact was assessed by reporting the mean increase/decrease of management changes normalized to baseline (n = 32 dermatologists). Benign GEP results prompted clinicians to decrease surgical margins (84.2%). Malignant GEP results escalated surgical excision recommendations (100%). A majority (72.2%) reduced and nearly all (98.9%) increased follow-up frequency for benign or malignant GEP results, respectively. There was an overall increase in management plan confidence with GEP results. Conclusion: Diagnostic GEP tests help guide clinical decision-making in a variety of diagnostically ambiguous or clinicopathologically discordant scenarios.
Dermatologists\' use of diagnostic gene expression profiles for personalized patient care. When your doctor takes a piece of a mole, that mole is looked at under the microscope by a pathologist. The pathologist is responsible for figuring out if the mole is dangerous or not. Dangerous moles are removed with surgery to make sure all the dangerous tissue is gone. Moles without a health threat are left alone. Sometimes figuring out how dangerous a mole is is difficult. The pathologist may not provide the doctor with enough information for them to know how to treat your mole. There is a test that can provide information on whether your mole is unsafe. This test is called diagnostic gene expression profiling or GEP. In this study, GEP is used to help doctors figure out how to treat a mole and how often the patient should be seen in the office for skin checks. With GEP, important changes in patient treatment were identified. These include the need for an additional surgery, how much healthy tissue should be removed during surgery and how often the patient should be seen in the office. For suspicious moles where the pathology report is unclear, GEP can provide information that leads to more appropriate and personalized patient care.
Ancillary diagnostic gene expression profile testing for ambiguous cutaneous melanocytic lesions helps optimize dermatologist recommendations for excision margin and follow-up.
Dermatologists\' use of diagnostic gene expression profiles for personalized patient care. When your doctor takes a piece of a mole, that mole is looked at under the microscope by a pathologist. The pathologist is responsible for figuring out if the mole is dangerous or not. Dangerous moles are removed with surgery to make sure all the dangerous tissue is gone. Moles without a health threat are left alone. Sometimes figuring out how dangerous a mole is is difficult. The pathologist may not provide the doctor with enough information for them to know how to treat your mole. There is a test that can provide information on whether your mole is unsafe. This test is called diagnostic gene expression profiling or GEP. In this study, GEP is used to help doctors figure out how to treat a mole and how often the patient should be seen in the office for skin checks. With GEP, important changes in patient treatment were identified. These include the need for an additional surgery, how much healthy tissue should be removed during surgery and how often the patient should be seen in the office. For suspicious moles where the pathology report is unclear, GEP can provide information that leads to more appropriate and personalized patient care.
Ancillary diagnostic gene expression profile testing for ambiguous cutaneous melanocytic lesions helps optimize dermatologist recommendations for excision margin and follow-up.
摘要：
目的：具有诊断和/或临床歧义的皮肤黑素细胞肿瘤给患者管理带来了挑战。方法：描述了六个具有诊断/临床不确定性的随机病例方案，有/没有良性或恶性诊断基因表达谱（GEP）结果。结果：通过报告标准化至基线的管理变化的平均增加/减少来评估临床影响（n=32名皮肤科医生）。良性GEP结果促使临床医生减少手术切缘(84.2%)。恶性GEP结果升级了手术切除建议（100％）。大多数（72.2％）减少，几乎所有（98.9％）增加良性或恶性GEP结果的随访频率，分别。管理计划对GEP结果的信心总体上有所提高。结论：诊断性GEP测试有助于在各种诊断模糊或临床病理不一致的情况下指导临床决策。
皮肤科医生将诊断基因表达谱用于个性化患者护理。当你的医生取出一块痣时，那个痣是由病理学家在显微镜下观察的。病理学家负责弄清楚痣是否危险。通过手术去除危险的痣，以确保所有危险的组织都消失了。没有健康威胁的痣是孤独的。有时很难弄清楚痣有多危险。病理学家可能无法向医生提供足够的信息，让他们知道如何治疗您的痣。有一个测试可以提供你的痣是否不安全的信息。该测试称为诊断基因表达谱或GEP。在这项研究中,GEP用于帮助医生弄清楚如何治疗痣，以及在办公室应多久见一次患者进行皮肤检查。有了GEP,确定了患者治疗中的重要变化。这些包括需要额外的手术，手术期间应该切除多少健康组织，以及患者应该在办公室看到的频率。对于病理报告不清楚的可疑痣，GEP可以提供导致更适当和个性化的患者护理的信息。
针对模糊皮肤黑色素细胞病变的辅助诊断基因表达谱检测有助于优化皮肤科医生对切除边缘和随访的建议。
皮肤科医生将诊断基因表达谱用于个性化患者护理。当你的医生取出一块痣时，那个痣是由病理学家在显微镜下观察的。病理学家负责弄清楚痣是否危险。通过手术去除危险的痣，以确保所有危险的组织都消失了。没有健康威胁的痣是孤独的。有时很难弄清楚痣有多危险。病理学家可能无法向医生提供足够的信息，让他们知道如何治疗您的痣。有一个测试可以提供你的痣是否不安全的信息。该测试称为诊断基因表达谱或GEP。在这项研究中,GEP用于帮助医生弄清楚如何治疗痣，以及在办公室应多久见一次患者进行皮肤检查。有了GEP,确定了患者治疗中的重要变化。这些包括需要额外的手术，手术期间应该切除多少健康组织，以及患者应该在办公室看到的频率。对于病理报告不清楚的可疑痣，GEP可以提供导致更适当和个性化的患者护理的信息。
针对模糊皮肤黑色素细胞病变的辅助诊断基因表达谱检测有助于优化皮肤科医生对切除边缘和随访的建议。
