未经证实:原发性中枢神经系统淋巴瘤(PCNSL)是一种侵袭性非霍奇金淋巴瘤的结外亚型。心室占优PCNSL,出现在中枢神经系统的心室系统,是一个罕见的实体。在90%以上的案例中,PCNSL被分类为弥漫性大B细胞淋巴瘤。很少,PCNSL可归类为粘膜相关淋巴组织(MALT)的边缘区B细胞淋巴瘤(MZBCL)。一起来看,在脑室中出现的原发性MALT型MZBCL是极为罕见的表现。
未经证实:一名69岁女性出现持续的左额叶头痛1年。磁共振成像显示左心室内的软组织病变增强,伴有相关的脑室周围水肿。我们对肿瘤进行了切除活检,严重有脑膜瘤的外观。肿瘤的组织病理学与MALT型的MZBCL一致。患者接受利妥昔单抗和依鲁替尼治疗。手术后六个月,她的神经系统完好无损,没有任何疾病。
未经证实:我们报告一例原发性MALT型MZBCL出现于中枢神经系统,具有模仿脑膜瘤的特征。该淋巴瘤累及侧脑室,可能起源于脉络丛。脑膜上皮细胞和脉络丛上皮细胞可在慢性炎症刺激下获得MALT,如感染或自身免疫性疾病。在极少数情况下,MALT淋巴瘤可能是这种发病机制的一部分。
UNASSIGNED: Primary central nervous system lymphoma (PCNSL) is an aggressive extranodal subtype of nonHodgkin\'s lymphoma. Ventricle-predominant PCNSL, arising in the CNS ventricular system, is a rare entity. In over 90% of cases, PCNSL is classified as diffuse large B-cell lymphoma. Rarely, PCNSL may be classified as marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (MALT). Taken together, a primary MALT-type MZBCL arising in a cerebral ventricle is an extremely rare presentation.
UNASSIGNED: A 69-year-old female presented with a persistent left frontal headache for 1 year. Magnetic resonance imaging revealed an enhancing soft-tissue lesion within the left lateral ventricle, with associated periventricular edema. We performed an excisional biopsy of the tumor, which grossly had the appearance of a meningioma. Histopathology of the tumor was consistent with MZBCL of the MALT type. The patient was treated with Rituximab and Ibrutinib. Six months after surgery, she remained neurologically intact and free of disease.
UNASSIGNED: We report the case of a primary MALT-type MZBCL arising in the CNS ventricular system, with characteristics mimicking meningioma. This lymphoma involved the lateral ventricle and likely originated from the choroid plexus. Meningothelial cells and epithelial cells in the choroid plexus may acquire MALT in response to chronic inflammatory stimuli, such as infection or autoimmune disease. In rare cases, MALT lymphoma may develop as part of this pathogenesis.