由于诊断延迟等因素,癌症被广泛认为是全球死亡率的主要原因。预后不良,复发的可能性很高。FGD5转录因子G反义RNA1(FGD5-AS1),一种新发现的长链非编码RNA,已经成为一种有希望的预后生物标志物,恶性肿瘤预后。这项荟萃分析旨在评估FGD5-AS1在各种癌症中的预后意义。
■通过五个电子数据库进行了系统搜索,以确定研究FGD5-AS1表达作为癌症预后因素的作用的研究。FGD5-AS1在恶性肿瘤中的价值通过比值比(ORs)和风险比(HRs)以及相应的95%置信区间(CIs)来估计。此外,GEPIA数据库用于进一步补充我们的结果.
■这项分析包括12项研究,涵盖了8种癌症类型的642例病例。高FGD5-AS1表达与不良总生存期(OS)显着相关(HR=2.04,95CI[1.72,2.42],P<0.00001),晚期肿瘤分期(OR=3.47,95CI[2.34,5.14],P<0.00001),淋巴结转移(LNM)(OR=1.79,95%CI[1.20,2.67],P=0.004),和较大的肿瘤大小(OR=5.25,95CI[2.68,10.30],P<0.00001)。此外,如使用GEPIA在线基因分析工具所证实的,FGD5-AS1表达在6种恶性肿瘤中显著上调.
■这项荟萃分析的结果表明,FGD5-AS1高表达与不同癌症类型的不良预后显着相关,提示FGD5-AS1可能是预测癌症预后的一个有前景的生物标志物。
■https://www.约克。AC.uk/inst/crd,标识符CRD42024552582。
UNASSIGNED: Cancer is widely recognized as a prominent contributor to global mortality due to factors such as delayed diagnosis, unfavorable prognosis, and high likelihood of recurrence. FGD5 transcription factor G antisense RNA 1(FGD5-AS1), a newly identified long non-coding RNA, has emerged as a promising prognostic biomarker, for malignancy prognosis. This meta-analysis aimed to assess the prognostic significance of FGD5-AS1 in various carcinomas.
UNASSIGNED: A systematic search was performed through five electronic databases to identify studies that investigating the role of FGD5-AS1 expression as a prognostic factor in carcinomas. The value of FGD5-AS1 in
malignancies was estimated by odds ratios (ORs) and hazard ratios (HRs) with a corresponding 95% confidence intervals (CIs). Furthermore, the GEPIA database was used to further supplement our results.
UNASSIGNED: This analysis included 12 studies with 642 cases covering eight cancer types. High FGD5-AS1 expression exhibited a significant correlation with poor overall survival(OS) (HR = 2.04, 95%CI [1.72, 2.42], P < 0.00001), advanced tumor stage (OR = 3.47, 95%CI [2.34, 5.14], P < 0.00001), lymph node metastasis(LNM) (OR = 1.79, 95% CI [1.20,2.67], P = 0.004), and larger tumor size (OR= 5.25, 95%CI [2.68, 10.30], P < 0.00001). Furthermore, the FGD5-AS1 expression was notably upregulated in six types of
malignancies as verified using the GEPIA online gene analysis tool.
UNASSIGNED: The findings of this meta-analysis indicated that high FGD5-AS1 expression was significantly associated with poor prognosis in diverse cancer types, suggesting that FGD5-AS1 may be a promising biomarker for predicting cancer prognosis.
UNASSIGNED: https://www.york.ac.uk/inst/crd, identifier CRD42024552582.