背景:由于生活方式和饮食习惯的变化,全球肥胖人口逐渐增加,导致肥胖个体数量显著增加。肥胖是由能量摄入和消耗之间的不平衡引起的,导致过多的脂肪堆积,干扰正常的人体新陈代谢.它也与心血管疾病有关,代谢综合征,男性生殖内分泌调节紊乱,全身和局部炎症反应,过度的氧化应激,和凋亡。所有这些因素都会破坏精子生成和成熟的内部环境,导致男性性功能障碍,精子质量下降,生育率较低。本研究从文献计量学的角度分析了肥胖对男性生殖障碍影响的趋势和重点。
方法:本研究使用WebofScience作为统计来源,覆盖所有时间跨度。像WebofScience这样的工具,VOSviewer,和城市空间被用来分析国家,机构,作者,期刊,和字段中的关键字。出版物总数,总引用次数,并选择平均引用次数进行统计。
结果:结果表明,肥胖对男性生殖功能影响的研究大致可分为三个阶段:初始阶段,缓慢发展的阶段,和快速发展阶段。我们的统计范围包括我们筛选的463篇高度相关的文章。我们发现该领域出版物最多的杂志是Andrologia,总引用次数最高的机构是犹他大学。最有影响力的国家,机构,这个领域的作者是美国,犹他大学,和Carrell,道格拉斯.目前,与肥胖对男性生殖影响相关的研究主要集中在三个方面:生物化学,分子生物学,和生殖生物学。关键词爆炸结果表明精子,肥胖,男性生殖处于该领域未来研究的前沿和趋势。已经从基础生化和分子研究转向依赖于组学技术的分子机制研究。然而,我们观察到,2022年发表的论文数量低于2021年,表明在此期间增长中断。考虑到这种偏差可能是由于COVID-19大流行的影响,它可能会阻碍2022年某些实验的进展。近年来,中国在这一领域的研究迅速发展。然而,平均引用率相对较低,这表明中国学者需要进一步提高论文质量。根据我们的研究,在全球肥胖的背景下,男性有增加不孕症的风险。解决这个问题依赖于我们对肥胖相关男性生殖障碍机制的持续研究。在过去的四十三年里,在全世界科学家的贡献下,这一领域的研究蓬勃发展。
结论:肥胖对男性生殖障碍的影响已被广泛研究。目前,该领域的研究主要集中在男性精子功能上,精子质量,以及细胞对男性生殖的影响或机制。该领域的未来趋势应集中在男性生育力与能量代谢之间的关系上,以及脂肪组织的内分泌功能。本研究全面分析了肥胖和男性生殖障碍的研究现状和全球趋势。我们还讨论了该领域的未来发展,使研究人员更容易理解它的发展历史,当前状态,和趋势,为该地区的有效勘探提供有价值的参考。
BACKGROUND: Due to changes in lifestyle and dietary habits, the global population with obesity is increasing gradually, resulting in a significant rise in the number of individuals having obesity. Obesity is caused by an imbalance between energy intake and consumption, leading to excessive fat accumulation, which interferes with normal human metabolism. It is also associated with cardiovascular disease, metabolic syndrome, male reproductive endocrine regulation disorders, systemic and local inflammatory reactions, excessive oxidative stress, and apoptosis. All these factors can damage the internal environment for sperm generation and maturation, resulting in male sexual dysfunction, a decline in sperm quality, and lower fertility. This study analyzes the trends and priorities of the effects of obesity on male reproductive disorders from a bibliometric perspective.
METHODS: This study uses the Web of Science as the statistical source, covering all time spans. Tools like Web of Science, VOSviewer, and CiteSpace are used to analyze countries, institutions, authors, journals, and keywords in the field. Total publications, total citations, and average number of citations are selected for statistics.
RESULTS: The results show that the research on the impact of obesity on male reproductive function can be roughly divided into three stages: the initial stage, the slow development stage, and the rapid development stage. Our statistical scope includes 463 highly relevant articles that we have screened. We found that the journal with the most publications in this field is Andrologia, and the institution with the highest total citations is the University of Utah. The most influential countries, institutions, and authors in this field are the United States, the University of Utah, and Carrell, Douglas. Currently, research related to the impact of obesity on male reproduction focuses mainly on three aspects: biochemistry, molecular biology, and reproductive biology. The keyword explosion results indicate that sperm, obesity, and male reproduction are at the forefront and trends of future research in this field. There has been a shift from basic biochemical and molecular research to research on molecular mechanisms relying on omics technologies. However, we have observed that the number of papers published in 2022 is lower than in 2021, indicating a growth interruption during this period. Considering that this deviation may be due to the impact of the COVID-19 pandemic, it may hinder the progress of certain experiments in 2022. In recent years, China has rapidly developed research in this field. However, the average citation rate is relatively low, indicating the need for Chinese scholars to improve the quality of their articles further. Based on our research and in the context of global obesity, men are at risk of increased infertility. Addressing this issue relies on our continued research into the mechanisms of obesity-related male reproductive disorders. Over the past forty-three years, with the contributions of scientists worldwide, research in this field has flourished.
CONCLUSIONS: The impact of obesity on male reproductive disorders has been extensively studied. Currently, research in this field primarily focuses on male sperm function, sperm quality, and the effects or mechanisms of cells on male reproduction. Future trends in this field should concentrate on the relationship between male fertility and energy metabolism, as well as the endocrine function of adipose tissue. This study comprehensively analyzes the current research status and global trends in obesity and male reproductive disorders. We also discuss the future developments in this field, making it easier for researchers to understand its developmental history, current status, and trends, providing valuable reference for effective exploration in this area.