PDF(Pubmed)
Abstract：
Spermatogenesis in mammalian testes is essential for male fertility, ensuring a continuous supply of mature sperm. The testicular microenvironment finely tunes this process, with retinoic acid, an active metabolite of vitamin A, serving a pivotal role. Retinoic acid is critical for various stages, including the differentiation of spermatogonia, meiosis in spermatogenic cells, and the production of mature spermatozoa. Vitamin A deficiency halts spermatogenesis, leading to the degeneration of numerous germ cells, a condition reversible with retinoic acid supplementation. Although retinoic acid can restore fertility in some males with reproductive disorders, it does not work universally. Furthermore, high doses may adversely affect reproduction. The inconsistent outcomes of retinoid treatments in addressing infertility are linked to the incomplete understanding of the molecular mechanisms through which retinoid signaling governs spermatogenesis. In addition to the treatment of male reproductive disorders, the role of retinoic acid in spermatogenesis also provides new ideas for the development of male non-hormone contraceptives. This paper will explore three facets: the synthesis and breakdown of retinoic acid in the testes, its role in spermatogenesis, and its application in male reproduction. Our discussion aims to provide a comprehensive reference for studying the regulatory effects of retinoic acid signaling on spermatogenesis and offer insights into its use in treating male reproductive issues.
摘要：
哺乳动物睾丸的精子发生对男性生育力至关重要，确保成熟精子的持续供应。睾丸微环境很好地调整了这个过程，视黄酸，维生素A的活性代谢产物,起到举足轻重的作用。维甲酸对各个阶段都至关重要，包括精原细胞的分化，生精细胞减数分裂,和成熟精子的生产。维生素A缺乏阻止精子发生，导致许多生殖细胞的退化，补充维甲酸是可逆的。尽管视黄酸可以恢复一些患有生殖障碍的男性的生育能力，它并不普遍工作。此外，高剂量可能会对生殖产生不利影响。类维生素A治疗在解决不育方面的不一致结果与对类维生素A信号控制精子发生的分子机制的不完全理解有关。除了治疗男性生殖障碍，维甲酸在精子发生中的作用也为男性非激素避孕药的发展提供了新思路。本文将探讨三个方面:视黄酸在睾丸中的合成和分解,它在精子发生中的作用，及其在男性生殖中的应用。我们的讨论旨在为研究视黄酸信号对精子发生的调节作用提供全面的参考，并为其在治疗男性生殖问题中的应用提供见解。
