■治疗脱发可能具有挑战性。可用的治疗方法是局部米诺地尔,低剂量口服米诺地尔(LDOM),和5-α还原酶抑制剂,如非那雄胺和度他雄胺。仅外用米诺地尔和非那雄胺每天1毫克是FDA批准的,其余的都在标签外使用。最近的研究表明,口服米诺地尔可能是女性雄激素性脱发(女性AGA)和男性雄激素性脱发(男性AGA)的安全有效治疗方法。
■在这篇评论中,我们探索药代动力学,作用机制,安全,口服米诺地尔的疗效。此外,我们讨论了与女性AGA和男性AGA可用的其他治疗方法相比的有效性。
■LDOM在多项试验中表现出良好的疗效和安全性。随后,其用于治疗男性AGA和女性AGA的用途正在增加。然而,它的使用仍然是标签外的,通过增加使用量,我们将更好地了解最佳剂量和监测指南。LDOM在其他形式的脱发中也具有一定的有效性。
UNASSIGNED: Treating alopecia can be challenging. The available treatments are topical minoxidil, low-dose oral minoxidil (LDOM), and 5-α reductase inhibitors like finasteride and dutasteride. Only topical minoxidil and finasteride 1 mg daily are FDA-approved, while the rest are used off-label. Recent research has suggested that oral minoxidil may be a safe and effective treatment for both female androgenetic alopecia (female AGA) and male androgenetic alopecia (male AGA).
UNASSIGNED: In this review, we explore the pharmacokinetics, mechanism of action, safety, and efficacy of oral minoxidil. Additionally, we discuss its effectiveness compared to other treatments available for female AGA and male AGA.
UNASSIGNED: LDOM has demonstrated a favorable efficacy and safety profile in several trials. Subsequently, its use for the treatment of male AGA and female AGA is increasing. However, its use remains off-label, and through increased usage, we will get a better idea of the best dosage and monitoring guidelines. LDOM has also been used with some effectiveness in other forms of hair loss.