Abstract：
Procedural management, including fractionated laser therapy, has been increasingly investigated for the management of androgenetic alopecia (AGA). However, no comprehensive resources exist detailing the efficacy of fractionated laser therapies used for the treatment of AGA. A systematic review investigating fractionated laser use for AGA was performed, separated into each distinct fractionated laser modality. A meta-analysis was performed to examine improvement in hair counts and hair shaft diameter. Fourteen studies were included for systematic review, which identified the use of erbium-glass, thulium, erbium-ytrrium:aluminum garnet (YAG), and carbon dioxide (CO2) fractionated laser for the treatment of AGA. In the meta-analysis, fractionated laser combination therapy showed significant improvement in hair shaft diameter (2.51, 95% CI 2.37-2.65, I2 = 90.54). Fractionated laser monotherapy alone significantly improved hair shaft diameter (2.28 95% CI 2.03-2.52, I2 = 91.20%). This effect was durable on subgroup analysis for both erbium-glass (2.36 95% CI 2.01-2.71, I2 = 92.05%) and thulium (1.61 95% CI 1.08-2.15, I2 = < 0.00%). There was no improvement in hair shaft count for any laser modality. Erbium-glass laser is an effective modality as either monotherapy or combination with topical/injectable therapies to improve hair shaft diameter in AGA.
摘要：
程序管理,包括分割激光治疗，对于雄激素性脱发（AGA）的管理进行了越来越多的研究。然而,目前尚无全面的资源详细说明用于治疗AGA的分割激光治疗的疗效.进行了系统评价，研究了分割激光在AGA中的使用，分成每个不同的分割激光模态。进行荟萃分析以检查毛发数量和毛干直径的改善。14项研究被纳入系统评价，确定了铒玻璃的用途，thulium,铒钇:铝石榴石(YAG),和二氧化碳（CO2）分馏激光用于治疗AGA。在荟萃分析中，分割激光联合治疗显示毛干直径显著改善(2.51,95%CI2.37-2.65,I2=90.54).单独分割激光单药治疗可显着改善毛干直径（2.2895％CI2.03-2.52，I2=91.20％）。这种效应在铒玻璃(2.3695%CI2.01-2.71,I2=92.05%)和铕(1.6195%CI1.08-2.15,I2=<0.00%)的亚组分析中是持久的。对于任何激光方式，毛干计数均无改善。铒玻璃激光是一种有效的方式，可以作为单一疗法或与局部/可注射疗法相结合，以改善AGA中的毛干直径。
