■囊样黄斑水肿(CME)是葡萄膜炎患者永久性视力障碍的主要原因,特别是在患有中间葡萄膜炎(IU)的患者中。这项研究旨在比较IU患者的黄斑微脉管系统的变化与葡萄膜无反应性CME和无黄斑水肿。
■在本病例对照研究中,评估了55只眼IU患者的黄斑微血管结构,包括血管密度,中央凹无血管区(FAZ)测量,血管形态变化,使用光谱域光学相干断层扫描血管造影(OCT-A)和AngioVueOCT-A系统。我们将患者分为以下两组:病例组,包括30只与IU相关的无反应性CME的眼睛,和对照组,包括25只眼IU无黄斑水肿。
■病例组和对照组的参与者具有相当的年龄(P=0.753)和性别(P=0.124)分布。与对照组相比,病例组的浅表毛细血管丛血管密度在整个图像中(P=0.027)和旁凹面积(P=0.001)显着降低。然而,两组在中央凹浅表血管密度方面无统计学差异,深毛细血管丛血管密度,FAZ区域,FAZ周边,FAZ准确性指数,或在FAZ周围300µm宽的环中的中央凹血管密度(所有P>0.05)。血管形态变化,比如毛细管簇,毛细血管扩张血管,或微动脉瘤,两组之间的OCT-A打印输出的概述图像没有差异。
■与IU相关的无反应性CME的眼的平均浅表毛细血管丛血管密度低于无黄斑水肿的眼。我们在SCP中观察到的囊样空间比在DCP中观察到的更多。内部视网膜的微囊性改变和缺血可能是无反应性CME的潜在原因。未来的前瞻性纵向研究与健康,匹配的对照是必要的,以证实我们的发现.
UNASSIGNED: Cystoid macular edema (CME) is the leading cause of permanent visual impairment in patients with uveitis, particularly in patients with intermediate uveitis (IU). This study was aimed at comparing the changes in the macular microvasculature in patients with IU with uveitic non-responsive CME and without macular edema.
UNASSIGNED: In this case-control study, 55 eyes of patients with IU were assessed for macular microvascular structures, including vascular density, foveal avascular zone (FAZ) measurement, and vascular morphological changes, using spectral-domain optical coherence tomography angiography (OCT-A) with the AngioVue OCT-A system. We divided patients into the following two groups: the case group, including 30 eyes with IU-related non-responsive CME, and the control group, including 25 eyes with IU without macular edema.
UNASSIGNED: Participants in the case and control groups had comparable age (P = 0.753) and sex (P = 0.124) distributions. Superficial capillary plexus vessel density in the case group was significantly decreased in the whole image (P = 0.027) and the parafoveal area (P = 0.001) compared to the control group. However, there were no statistically significant differences between the two groups in terms of foveal superficial vessel density, deep capillary plexus vessel density, FAZ area, FAZ perimeter, FAZ acircularity index, or foveal vessel density in a 300-µm-wide annulus around the FAZ (all P > 0.05). Vascular morphological changes, such as the capillary tuft, telangiectatic vessels, or micro-aneurism, were not different in the overview images of the OCT-A printout between the two groups.
UNASSIGNED: The mean superficial capillary plexus vessel density was lower in eyes with IU-related nonresponsive CME than in those without macular edema. We observed more cystoid spaces in SCP than in DCP. Microcystic changes in the inner retina and ischemia may be the underlying cause in eyes with nonresponsive CME. Future prospective longitudinal studies with healthy, matched controls are warranted to confirm our findings.