■已经批准了几种针对COVID-19的疫苗,其中5种已经在印度尼西亚使用。由于抗体水平的下降3至6个月后的第二剂量的CoronaVac,医护人员接受了第三次加强mRNA疫苗(mRNA-1273)以提高抗体水平.本研究旨在评估医护人员抗S-RBDIgG水平差异的危险因素。
■这项研究是一项回顾性队列研究,对576名以前没有SARS-CoV-2感染的医护人员进行了回顾性队列研究,他们在第二次剂量后6个月接受了2剂CoronaVac和第三剂mRNA-1273。第二次获得血样,6th,12th,第二剂CoronaVac疫苗给药后24周,在第20周使用mRNA-1273加强剂。用Elecsys抗SARS-CoV-2S免疫测定进行IgG抗体的定量测量。我们使用单变量和多变量线性回归分析确定了预测疫苗接种后抗体滴度的基线因素。
■这项研究包括576名32岁的参与者,72.05%女性,45.84%来自高危职业亚组。2日的中位抗体滴度水平,6th,12th,第二剂疫苗给药后第24周为40.99u/mL,42.01u/mL,54.78u/mL,和23,225u/mL。女性和年轻年龄组(20-29岁)的抗体水平最高。
■第三剂疫苗提高了SARS-CoV-2峰值IgG抗体的定量滴度,并消除了按性别划分的抗体滴度差异。
UNASSIGNED: Several vaccines have been approved against COVID-19, and 5 have been used in Indonesia. Due to the decrease in antibody levels 3 to 6 months after the second dose of CoronaVac, healthcare workers received the third booster of mRNA vaccine (mRNA-1273) to increase the antibody level. This study aimed to evaluate the risk factors of anti-S-RBD IgG levels differences in healthcare workers.
UNASSIGNED: This study is a retrospective cohort study of 576 healthcare workers without previous SARS-CoV-2 infection who received 2 doses of CoronaVac and the third dose of mRNA-1273 6 months after the second dose. Blood samples were obtained 2nd, 6th, 12th, and 24th weeks after the second dose of CoronaVac vaccine administration, with mRNA-1273 booster on week 20. Quantitative measurements of IgG antibodies were performed with Elecsys Anti-SARS-CoV-2 S immunoassay. We identify the baseline factors predicting post-vaccination antibody titers using univariate and multivariate linear regression analysis.
UNASSIGNED: This study comprised 576 participants aged 32 years old, 72.05% female, and 45.84% from high-risk occupation subgroups. The median antibodies titer level on the 2nd, 6th, 12th, and 24th weeks after the second vaccine dose administration were 40.99 u/mL, 42.01 u/mL, 54.78 u/mL, and 23,225 u/mL. Antibody levels trended highest in female and younger age group (20-29 years old).
UNASSIGNED: The third dose of vaccine increased the quantitative SARS-CoV-2 spike IgG antibody titers and eliminated differences in antibodies titer by gender.