■这项荟萃分析是为了分析临床表现,磁共振成像(MRI)特征,和淋巴细胞性垂体炎(LYH)的管理。
■从2010年1月至2020年12月检索了四个不同的数据库,两名研究人员独立进行了文献筛选,数据提取,和质量评估。我们使用随机效应荟萃分析以95%CI计算总相对风险。
■这项荟萃分析显示,LYH患者中女性的百分比为78%。15%的女性患者LYH与妊娠有关,头痛(49%)和中枢神经性尿崩症(CDI)的症状(45%)是最常见的表现。在24%的LYH患者中,与另一种自身免疫性疾病有关.继发性性腺功能减退的发生率,继发性肾上腺功能减退,继发性甲状腺功能减退,生长激素缺乏是54%,49%,43%,22%,分别。垂体对比增强(63%),对称垂体肿大(60%),垂体柄增厚(58%),鞍区包块或鞍上延伸(58%),垂体后叶高强度丢失(50%)是典型的MRI表现。关于LYH治疗,观察或激素替代的患者百分比,类固醇治疗,手术率是43%,36%,34%,分别。
■充分了解淋巴细胞性垂体炎的临床特征具有重要意义,减少漏诊和误诊,避免不必要的手术,维持正常的垂体功能。
UNASSIGNED: This meta-analysis was performed to analyze the clinical presentation, magnetic resonance imaging (MRI) characteristics, and the management of lymphocytic hypophysitis (LYH).
UNASSIGNED: Four different databases were searched from January 2010 to December 2020, two researchers independently conducted literature screening, data extraction, and quality evaluation. We used a random effects meta-analysis to calculate summary relative risks with 95% CI.
UNASSIGNED: This meta-analysis showed that the percentage of women among LYH patients was 78%. LYH was associated with pregnancy in 15% of female patients, with headache (49%) and symptoms of central diabetes insipidus (CDI) (45%) being the most frequent presentation. In 24% of LYH patients, there was an association with another autoimmune disease. The incidence of secondary hypogonadism, secondary hypoadrenalism, secondary hypothyroidism, and growth hormone deficit was 54%, 49%, 43%, and 22%, respectively. Pituitary contrast enhancement (63%), symmetrical pituitary enlargement (60%), thickening of the pituitary stalk (58%), sella mass or suprasellar extension (58%), and loss of posterior pituitary hyperintensity (50%) were typical MRI findings. Regarding LYH treatment, the percentage of patients who had observation or hormone replacement, steroid therapy, and surgery was 43%, 36%, and 34%, respectively.
UNASSIGNED: It is of great significance to fully understand the clinical characteristics of lymphocytic hypophysitis, reduce missed diagnosis and misdiagnosis, avoid unnecessary surgery and maintain normal pituitary function.