PDF(Pubmed)
Abstract：
UNASSIGNED: Lymphocytic hypophysitis is an underestimated disease and the pathogenesis is still poorly elucidated. Post-coronavirus lymphocytic hypophysitis is a new emerging entity.
METHODS: A 16-year-old previously healthy girl presented with pituitary tumor syndrome. She suffered from frontal headaches, polyuria-polydipsic syndrome, and impaired visual acuity. She was diagnosed with COVID-19 infection three weeks before. Contrast-enhanced magnetic resonance imaging (MRI) revealed pituitary enlargement with intense homogenous enhancement postgadolinium on T1 weighted images. The diagnosis of lymphocytic hypophysitis was made after ruling out other differential diagnosis. She was started on methylprednisolone. Improvement of clinical symptoms was seen on day 5 with a significant decrease in headache intensity.
UNASSIGNED: The article summarizes data from cases reported in the literature and our case to highlight coronavirus as a new trigger of lymphocytic hypophysitis. Despite the rarity of this complication, patients with a suspicion of hypophysitis after a recent COVID-19 infection should be carefully evaluated.
CONCLUSIONS: COVID-19 infection can cause lymphocytic hypophysitis. However, it seems premature to conclude on the causal link between COVID-19 and endocrine diseases. Further studies on larger samples are needed to comprehend the pathogenesis of autoimmune endocrinopathies after COVID-19 infection.
METHODS: A 16-year-old previously healthy girl presented with pituitary tumor syndrome. She suffered from frontal headaches, polyuria-polydipsic syndrome, and impaired visual acuity. She was diagnosed with COVID-19 infection three weeks before. Contrast-enhanced magnetic resonance imaging (MRI) revealed pituitary enlargement with intense homogenous enhancement postgadolinium on T1 weighted images. The diagnosis of lymphocytic hypophysitis was made after ruling out other differential diagnosis. She was started on methylprednisolone. Improvement of clinical symptoms was seen on day 5 with a significant decrease in headache intensity.
UNASSIGNED: The article summarizes data from cases reported in the literature and our case to highlight coronavirus as a new trigger of lymphocytic hypophysitis. Despite the rarity of this complication, patients with a suspicion of hypophysitis after a recent COVID-19 infection should be carefully evaluated.
CONCLUSIONS: COVID-19 infection can cause lymphocytic hypophysitis. However, it seems premature to conclude on the causal link between COVID-19 and endocrine diseases. Further studies on larger samples are needed to comprehend the pathogenesis of autoimmune endocrinopathies after COVID-19 infection.
摘要：
■淋巴细胞性垂体炎是一种被低估的疾病，其发病机制尚不清楚。冠状病毒后淋巴细胞性垂体炎是一种新兴的实体。
方法：一名16岁以前健康的女孩出现垂体肿瘤综合征。她患有额叶头痛,多尿-多相综合征,视力受损。三周前，她被诊断出患有COVID-19感染。对比增强的磁共振成像（MRI）显示，在T1加权图像上，垂体肿大并具有强烈的同质增强后钆。排除其他鉴别诊断后，诊断为淋巴细胞性垂体炎。她开始服用甲基强的松龙。在第5天观察到临床症状的改善,头痛强度显著降低。
■本文总结了文献中报道的病例和我们的病例的数据，以强调冠状病毒是淋巴细胞性垂体炎的新触发因素。尽管这种并发症很少，近期COVID-19感染后怀疑有垂体炎的患者应仔细评估.
结论：COVID-19感染可引起淋巴细胞性垂体炎。然而,就COVID-19与内分泌疾病之间的因果关系得出结论似乎为时过早。需要对更大样本进行进一步研究，以了解COVID-19感染后自身免疫性内分泌病的发病机理。
方法：一名16岁以前健康的女孩出现垂体肿瘤综合征。她患有额叶头痛,多尿-多相综合征,视力受损。三周前，她被诊断出患有COVID-19感染。对比增强的磁共振成像（MRI）显示，在T1加权图像上，垂体肿大并具有强烈的同质增强后钆。排除其他鉴别诊断后，诊断为淋巴细胞性垂体炎。她开始服用甲基强的松龙。在第5天观察到临床症状的改善,头痛强度显著降低。
■本文总结了文献中报道的病例和我们的病例的数据，以强调冠状病毒是淋巴细胞性垂体炎的新触发因素。尽管这种并发症很少，近期COVID-19感染后怀疑有垂体炎的患者应仔细评估.
结论：COVID-19感染可引起淋巴细胞性垂体炎。然而,就COVID-19与内分泌疾病之间的因果关系得出结论似乎为时过早。需要对更大样本进行进一步研究，以了解COVID-19感染后自身免疫性内分泌病的发病机理。
