结节病以产生各种各样的皮肤病变而臭名昭著,分类为特定或非特定。特定病变包括从微丘疹到皮下结节的原发性形态。非特异性皮肤病变包括相关疾病,如结节性红斑,角质层钙质沉着,还有Prurigo.患者具有特异性和非特异性病变的组合并不少见。相比之下,1例患者有多个特定的肉瘤病变是非常罕见的。当存在时,术语“多形性皮肤结节病”已被使用。我们介绍了一个患者的病例,该患者表现为结节病的三种特定皮肤形态:丘疹性结节病,Darier-Roussy皮下结节病,和狼疮。口服米诺环素仅两个月后,我们的患者表现出显着的改善,皮肤病变几乎完全消退。除了描述罕见的多态表现,该病例还强调了当存在多种形态时,将病变类型与总体预后联系起来的挑战.
Sarcoidosis is notorious for producing a wide variety of skin lesions, which are categorized as either specific or nonspecific. The specific lesions include primary morphologies ranging from micropapules to subcutaneous nodules. Nonspecific skin lesions include associated conditions like erythema nodosum, calcinosis cutis, and prurigo. It is not uncommon for a patient to have a combination of specific and nonspecific lesions. In contrast, it is exceedingly rare for one patient to have multiple specific sarcoidal lesions. When present, the term \"polymorphous cutaneous sarcoidosis\" has been used. We present the case of a patient who presented with three specific cutaneous morphologies of sarcoidosis: papular sarcoid, Darier-Roussy subcutaneous sarcoidosis, and lupus pernio. After only two months of oral minocycline, our patient demonstrated remarkable improvement with near-complete resolution of the cutaneous lesions. In addition to describing the rare polymorphous presentation, this case also highlights the challenge of relating lesion type to overall prognosis when multiple morphologies are present.