■慢性下背痛(cLBP),经常归因于腰椎间盘突出症(LDH),对日常活动施加了实质性限制。尽管流行,下背部疼痛的神经机制仍未完全阐明。功能磁共振成像(fMRI)是一种广泛用于研究神经科学中神经可塑性变化的非侵入性方式。在这项研究中,基于任务和静息状态的功能磁共振成像方法被用来探测下背痛的中枢机制。
■该研究包括71例因LDH和80岁的慢性下背痛患者(cLBP组),性别,和教育匹配的健康志愿者(HC组)。受试者主要为中老年人。视觉模拟量表(VAS),Oswestry残疾指数(ODI),并记录日本骨科协会评分(JOA)。收集静息状态和基于任务的fMRI数据。
■在年龄上没有观察到显著差异,性别,两组之间的教育水平。在任务执行期间的cLBP组中,在初级运动皮层和辅助运动区观察到弥漫性和降低的激活。此外,在休息状态,在大脑区域检测到显著的变化,特别是在额叶,初级感官区域,初级运动皮层,precuneus,和尾状核,伴随着低频波动幅度的变化,区域同质性,度中心,和功能连接。这些发现表明,慢性下腰痛可能会导致任务期间感觉运动区域的兴奋性降低,而在静息状态期间感觉运动网络的活动增强。以及不同大脑区域功能连接的改变。
UNASSIGNED: Chronic lower back pain (cLBP), frequently attributed to lumbar disk herniation (LDH), imposes substantial limitations on daily activities. Despite its prevalence, the neural mechanisms underlying lower back pain remain incompletely elucidated. Functional magnetic resonance imaging (fMRI) emerges as a non-invasive modality extensively employed for investigating neuroplastic changes in neuroscience. In this study, task-based and resting-state fMRI methodologies are employed to probe the central mechanisms of lower back pain.
UNASSIGNED: The study included 71 chronic lower back pain patients (cLBP group) due to LDH and 80 age, gender, and education-matched healthy volunteers (HC group). The subjects are mainly middle-aged and elderly individuals. Visual Analog Scale (VAS), Oswestry Disability Index (ODI), and Japanese Orthopedic Association Scores (JOA) were recorded. Resting-state and task-based fMRI data were collected.
UNASSIGNED: No significant differences were observed in age, gender, and education level between the two groups. In the cLBP group during task execution, there was diffuse and reduced activation observed in the primary motor cortex and supplementary motor area. Additionally, during resting states, notable changes were detected in brain regions, particularly in the frontal lobe, primary sensory area, primary motor cortex, precuneus, and caudate nucleus, accompanied by alterations in Amplitude of Low Frequency Fluctuation, Regional Homogeneity, Degree Centrality, and functional connectivity. These findings suggest that chronic lower back pain may entail reduced excitability in sensory-motor areas during tasks and heightened activity in the sensory-motor network during resting states, along with modified functional connectivity in various brain regions.