PDF(Pubmed)
Abstract：
UNASSIGNED: Condoliase-based chemonucleolysis is a minimally invasive intermediate treatment option between conservative approaches and surgical interventions for lumbar disk herniation (LDH). In this study, the effects of psychological factors on the clinical outcomes of condoliase therapy for LDH were assessed.
UNASSIGNED: This study involved patients with LDH who received condoliase injections over a 1-year follow-up period. Data from the visual analog scale (VAS) scores for leg and back pain, Oswestry Disability Index, and Hospital Anxiety and Depression Scale (HADS), which was utilized for the psychological assessment, were collected. Using magnetic resonance imaging, changes in disk height and degeneration were evaluated. Data were assessed at baseline and 1-month, 3-month, and 1-year follow-ups. Condoliase therapy was considered effective in patients whose VAS score for leg pain improved by ≥50% at 1 year from baseline and who did not require surgery. The patients were divided into two groups: those who reported effective treatment (Group E) and those who did not (Group I). Between these two groups, comparative analyses were carried out.
UNASSIGNED: In this study, a total of 102 patients (70 men; mean age, 43.8±18.2 years) were included. Condoliase therapy was effective in 76 patients (74.5%). Thirty-five patients (34.3%) showed psychological factors (HADS-Anxiety [HADS-A]≥8 or HADS-Depression [HADS-D]≥8) preoperatively and had a significantly lower rate of effectiveness than did those without psychological factors. Group I demonstrated significantly higher baseline back pain VAS, HADS, and HADS-D scores when compared with Group E. Logistic regression analysis identified females and the baseline HADS-D score as independent factors that were related to the effectiveness of condoliase therapy.
UNASSIGNED: The patients with psychological factors tended to experience residual pain resulting in adverse effects on the clinical outcomes of chemonucleolysis with condoliase.
UNASSIGNED: This study involved patients with LDH who received condoliase injections over a 1-year follow-up period. Data from the visual analog scale (VAS) scores for leg and back pain, Oswestry Disability Index, and Hospital Anxiety and Depression Scale (HADS), which was utilized for the psychological assessment, were collected. Using magnetic resonance imaging, changes in disk height and degeneration were evaluated. Data were assessed at baseline and 1-month, 3-month, and 1-year follow-ups. Condoliase therapy was considered effective in patients whose VAS score for leg pain improved by ≥50% at 1 year from baseline and who did not require surgery. The patients were divided into two groups: those who reported effective treatment (Group E) and those who did not (Group I). Between these two groups, comparative analyses were carried out.
UNASSIGNED: In this study, a total of 102 patients (70 men; mean age, 43.8±18.2 years) were included. Condoliase therapy was effective in 76 patients (74.5%). Thirty-five patients (34.3%) showed psychological factors (HADS-Anxiety [HADS-A]≥8 or HADS-Depression [HADS-D]≥8) preoperatively and had a significantly lower rate of effectiveness than did those without psychological factors. Group I demonstrated significantly higher baseline back pain VAS, HADS, and HADS-D scores when compared with Group E. Logistic regression analysis identified females and the baseline HADS-D score as independent factors that were related to the effectiveness of condoliase therapy.
UNASSIGNED: The patients with psychological factors tended to experience residual pain resulting in adverse effects on the clinical outcomes of chemonucleolysis with condoliase.
摘要：
■基于Condoliase的化学溶核术是一种介于保守方法和手术干预之间的微创中间治疗选择腰椎间盘突出症（LDH）。在这项研究中,评估了心理因素对condoliase治疗LDH临床结局的影响.
■这项研究涉及LDH患者，这些患者在1年的随访期内接受了condoliase注射。来自腿部和背部疼痛的视觉模拟量表（VAS）评分的数据，Oswestry残疾指数,和医院焦虑和抑郁量表（HADS），用于心理评估，被收集。使用磁共振成像，评估了椎间盘高度和退变的变化。数据在基线和1个月时进行评估，3个月,和1年的随访。腰果酶治疗被认为是有效的患者，患者的VAS评分改善≥50％，从基线1年，谁不需要手术。将患者分为两组：报告有效治疗的患者（E组）和未有效治疗的患者（I组）。在这两组之间，进行了比较分析。
■在这项研究中，共有102名患者(70名男性；平均年龄，包括43.8±18.2年）。Condoliase治疗有效76例（74.5％）。35例（34.3％）患者术前表现出心理因素（HADS-焦虑[HADS-A]≥8或HADS-抑郁[HADS-D]≥8），其有效率明显低于没有心理因素的患者。第一组表现出明显较高的基线背痛VAS，HADS,与E组比较时,和HADS-D评分。Logistic回归分析将女性和基线HADS-D评分确定为与condoliase治疗有效性相关的独立因素。
■有心理因素的患者往往会出现残余疼痛，从而对condoliase化学核溶解术的临床结局产生不利影响。
■这项研究涉及LDH患者，这些患者在1年的随访期内接受了condoliase注射。来自腿部和背部疼痛的视觉模拟量表（VAS）评分的数据，Oswestry残疾指数,和医院焦虑和抑郁量表（HADS），用于心理评估，被收集。使用磁共振成像，评估了椎间盘高度和退变的变化。数据在基线和1个月时进行评估，3个月,和1年的随访。腰果酶治疗被认为是有效的患者，患者的VAS评分改善≥50％，从基线1年，谁不需要手术。将患者分为两组：报告有效治疗的患者（E组）和未有效治疗的患者（I组）。在这两组之间，进行了比较分析。
■在这项研究中，共有102名患者(70名男性；平均年龄，包括43.8±18.2年）。Condoliase治疗有效76例（74.5％）。35例（34.3％）患者术前表现出心理因素（HADS-焦虑[HADS-A]≥8或HADS-抑郁[HADS-D]≥8），其有效率明显低于没有心理因素的患者。第一组表现出明显较高的基线背痛VAS，HADS,与E组比较时,和HADS-D评分。Logistic回归分析将女性和基线HADS-D评分确定为与condoliase治疗有效性相关的独立因素。
■有心理因素的患者往往会出现残余疼痛，从而对condoliase化学核溶解术的临床结局产生不利影响。
