■分析发作间状态和癫痫发作状态下来自丘脑前核(ANT)的局灶性耐药癫痫(DRE)患者的局部场电位(LFP)。
■在4例局灶性颞叶癫痫患者中研究了ANT立体定向脑电图(SEEG)记录。SEEG数据分为发作间和发作状态,并分为心电图(ESz),局灶性意识癫痫发作(FAS),意识受损的焦点(FIA),或双侧强直阵挛性发作(FBTC)的局灶性发作。在4Hz下分析LFP,8Hz,16Hz,32Hz,高伽马(100Hz),和波纹(200Hz),使用频谱图分析以及癫痫发作期间平均的归一化功率谱密度(PSD)与发作前基线段的统计比较。
■分析了162例癫痫发作的LFP记录(127ESz,23FAS,6国际汽联,和6FBTC)。根据时频数据(频谱图),广泛的活动,发生在2和6Hz之间,以4Hz为中心,在发作间状态下观察到频谱图上特别在8Hz处发生的细带活动。对于FAS,LFP-PSD有统计学意义的变化,国际汽联,和FBTC。我们在4Hz的FAS期间观察到LFP在较低频带的显着增益,国际汽联,和FBTC在4、8和16Hz,同时还观察到在100和200Hz的FBTC期间在较高频率下的增加,以及在32Hz的FAS发作期间的减少。相比之下,电图癫痫发作未发现LFP功率有显著变化.
■我们从有限的数据集中观察到所有临床癫痫发作类型,但不是电子惊厥,根据相关功率谱密度(PSD)的大小,导致ANT-LFP发生变化。未来的工作将需要验证在这些频率下使用ANT-LFP作为癫痫发作发生和严重程度的准确测量。这项工作代表了在局灶性癫痫发作和开发适应性DBS策略期间了解ANT丘脑LFP模式的第一步。
UNASSIGNED: To analyze the local field potentials (LFPs) in patients with focal drug-resistant epilepsy (DRE) from the anterior nucleus of the thalamus (ANT) during inter-ictal state and seizure state.
UNASSIGNED: ANT stereotactic EEG (SEEG) recordings were studied in four patients with focal temporal lobe epilepsy. SEEG data was classified as inter-ictal and ictal state and sub-categorized into electrographic (ESz), focal aware seizure (FAS), focal with impaired awareness (FIA), or focal to bilateral tonic-clonic seizure (FBTC). LFP was analyzed at 4 Hz, 8 Hz, 16 Hz, 32 Hz, high gamma (100 Hz), and ripples (200 Hz) using spectrogram analysis and a statistical comparison of normalized power spectral density (PSD) averaged during seizures versus pre-ictal baseline segments.
UNASSIGNED: The LFP recordings were analyzed for 162 seizures (127 ESz, 23 FAS, 6 FIA, and 6 FBTC). Based on time-frequency data (spectrogram), a broad band of activity, occurring between 2 and 6 Hz and centered at 4 Hz, and thin-band activity occurring specifically at 8 Hz on the frequency spectrogram were observed during the inter-ictal state. Statistically significant changes in LFP-PSD were seen for FAS, FIA, and FBTC. We observed a significant gain in LFP at the lower frequency band during FAS at 4 Hz, FIA, and FBTC at 4, 8, and 16 Hz while also observing increases at higher frequencies during FBTC at 100 and 200 Hz and a decrease during FAS seizures at 32 Hz. In contrast, no significant change in LFP power was seen for electrographic seizures.
UNASSIGNED: Our observations from a limited dataset indicate that all clinical seizure types, but not electrographic seizures, caused a change in ANT-LFP based on the magnitude of the associated power spectral density (PSD). Future work will be needed to validate the use of ANT-LFP at these frequencies as accurate measurements of seizure occurrence and severity. This work represents a first step toward understanding ANT thalamic LFP patterns during focal seizures and developing adaptive DBS strategies.