Abstract：
OBJECTIVE:
Recent innovative neurostimulators allow recording local field potentials (LFPs) while performing motor tasks monitored by wearable sensors. Inertial sensors can provide quantitative measures of motor impairment in people with subthalamic nucleus deep brain stimulation. To the best of our knowledge, there is no validated method to synchronize inertial sensors and neurostimulators without an additional device. This study aims to define a new synchronization method to analyze disease-related brain activity patterns during specific motor tasks and evaluate how LFPs are affected by stimulation and medication.
Approach:
Twelve male subjects treated with subthalamic nucleus deep brain stimulation were recruited to perform motor tasks in four different medication and stimulation conditions. In each condition, a synchronization protocol was performed consisting of taps on the implanted device, which produces artifacts in the LFPs that an inertial sensor can simultaneously record.
Main results:
In 64% of the recruited subjects, induced artifacts were detected at least once. Among those subjects, 83% of the recordings could be correctly synchronized offline. The remaining recordings were synchronized by video analysis.
Significance:
The proposed synchronization method does not require an external system and can be easily integrated into clinical practice. The procedure is simple and can be carried out in a short time. A proper and simple synchronization will also be useful to analyze subthalamic neural activity in the presence of specific events (e.g., freezing of gait events) to identify predictive biomarkers.
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摘要：
目的：＆＃xD;最近的创新神经刺激器允许记录局部场电位（LFP），同时执行可穿戴传感器监测的运动任务。惯性传感器可以为患有丘脑底核深部脑刺激的人提供运动障碍的定量测量。据我们所知,没有经过验证的方法在没有额外设备的情况下同步惯性传感器和神经刺激器。这项研究旨在定义一种新的同步方法，以分析特定运动任务期间与疾病相关的大脑活动模式，并评估刺激和药物如何影响LFP。＆＃xD;方法：＆＃xD;招募了十二名接受丘脑下核深部脑刺激治疗的男性受试者，以在四种不同的药物和刺激条件下执行运动任务。在每种情况下，执行了由植入设备上的抽头组成的同步协议，这在惯性传感器可以同时记录的LFP中产生伪影。＆＃xD;主要结果：＆＃xD;在64％的招募科目中，至少检测到一次诱导的伪影。在这些科目中，83％的录音可以离线正确同步。剩余的记录通过视频分析进行同步。＆＃xD;意义：＆＃xD;所提出的同步方法不需要外部系统，可以轻松地集成到临床实践中。该程序简单，可以在短时间内进行。适当而简单的同步也将有助于在存在特定事件的情况下分析丘脑下的神经活动（例如，步态事件的冻结)以确定预测性生物标志物。
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