背景:快感障碍是单相和双相抑郁患者的核心症状。然而,缺乏反映生物异质性的性别特异性标记。新出现的证据表明,免疫炎症标志物和脂蛋白谱的性别差异与快感缺乏症有关。
方法:人口统计学和临床数据,免疫炎症标志物(CD3,CD4和CD8),和脂蛋白谱[TC,TG,LDL-C,HDL-C,收集227例单相和双相抑郁患者的脂蛋白(a)Lp(a)]。汉密尔顿抑郁量表(HAMD)和Snaith-Hamilton快乐量表(SHAPS)用于评估抑郁和快感缺乏症状。数据采用方差分析,逻辑回归,和接收器工作特性曲线。
结果:男性患者的CD3,CD4和CD8水平高于非快感组,而Lp(a)水平较低,而在有和没有快感缺乏的女性患者中没有发现显着差异。Logistic回归分析显示,CD3、CD4、CD8和Lp(a)水平与男性患者快感缺乏相关。此外,在男性患者中,CD3,CD4,CD8和Lp(a)的组合对区分快感缺失的预测价值比个体参数最强.
结论:我们确定了免疫炎症标志物之间的性别特异性关联,脂蛋白概况,单相和双相抑郁患者的快感缺乏。CD3,CD4,CD8和Lp(a)的组合可能是识别单相和双相抑郁男性患者快感缺失的可能生物标志物。
Anhedonia is a core symptom in patients with unipolar and bipolar depression. However, sex-specific markers reflecting biological heterogeneity are lacking. Emerging evidence suggests that sex differences in immune-inflammatory markers and lipoprotein profiles are associated with anhedonia.
The demographic and clinical data, immune-inflammatory markers (CD3, CD4, and CD8), and lipoprotein profiles [TC, TG, LDL-C, HDL-C, lipoprotein(a) Lp (a)] of 227 patients with unipolar and bipolar depression were collected. The Hamilton Depression Rating Scale (HAMD) and Snaith-Hamilton Pleasure Scale (SHAPS) were used to assess depression and anhedonia symptoms. Data were analyzed using ANOVA, logistic regression, and receiver operating characteristic curves.
Male patients in the anhedonia group had higher levels of CD3, CD4, and CD8, and lower levels of Lp (a) than the non-anhedonia group, while no significant difference was identified in female patients with and without anhedonia. Logistic regression analysis showed that CD3, CD4, CD8, and Lp (a) levels were associated with anhedonia in male patients. Furthermore, the combination of CD3, CD4, CD8, and Lp (a) had the strongest predictive value for distinguishing anhedonia in male patients than individual parameters.
We identified sex-specific associations between immune-inflammatory markers, lipoprotein profiles, and anhedonia in patients with unipolar and bipolar depression. The combination of CD3, CD4, CD8, and Lp (a) might be a possible biomarker for identifying anhedonia in male patients with unipolar and bipolar depression.