■结核杆菌的特征是在有免疫能力的个体中对结核分枝杆菌或其产物的延迟型免疫反应。我们在此描述了来自印度北部三级护理中心的结核病患者的临床流行病学特征和对治疗的反应。
■这是对结核病诊所招募的所有皮肤结核病(TB)患者(2000-2019年)的临床记录的回顾性分析。考虑对符合结核杆菌诊断标准的患者记录进行分析。
■共有225名患者参加了结核病诊所;34例被诊断为结核菌。在这34个案例中,21人被确定为LS,2Bazin的硬红斑,1丘疹性结核杆菌,和10个结节性红斑。15/34(44.1%)的患者存在与开放性结核病病例的接触史。在15/34(44.1%)患者中发现了卡介苗接种史。在20/34(58.8%)患者中可以确定潜在结核病的重点。所有患者均进行皮肤活检。在所有患者中,诊断通过临床病理相关性得到证实,TST阳性,以及结核病的基本焦点。所有患者均接受6个月的一线药物抗结核治疗方案。
■在这项研究中,我们展示了各种形式的结核杆菌;苔藓是最常见的形式。我们还包括结节性红斑病例,对ATT反应良好。从我们的研究观察表明,结核杆菌是潜在的结核感染的重要皮肤标志物,这有助于早期发现隐匿性结核病和及时管理。
UNASSIGNED: Tuberculides are characterised by delayed-type of immunologic reactions to Mycobacterium tuberculosis or its products in immuno-competent individuals. We herein describe clinico-epidemiological features and response to treatment in patients with tuberculides from a tertiary care centre from North India.
UNASSIGNED: This was a retrospective analysis of the clinical records of all the cutaneous tuberculosis (TB) patients (year 2000-2019) enrolled in the TB clinic. The patient records fulfilling the diagnostic criteria of tuberculides were considered for analysis.
UNASSIGNED: A total of 225 patients attended the tuberculosis clinic; out of this, 34 were diagnosed as tuberculides. Out of these 34 cases, 21 were identified as LS, 2 erythema induratum of Bazin, 1 papulonecrotic tuberculide, and 10 erythema nodosum. History of contact to open cases of TB was present in 15/34 (44.1%) patients. History of BCG vaccination was found in 15/34 (44.1%) patients. The focus of underlying TB could be identified in 20/34 (58.8%) patients. Skin biopsy was performed in all patients. In all patients, the diagnosis was confirmed by clinico-pathological correlation, positive TST, and the underlying focus of TB. All patients received 6 months regimen of anti-tubercular therapy with first-line drugs.
UNASSIGNED: In this study, we demonstrated various forms of tuberculides; lichen scrofulosorum was the most common form. We also included erythema nodosum cases also, which responded well to ATT. Observation from our study showed that tuberculides are important cutaneous markers for underlying tuberculosis infection, which helps in early detection of occult tuberculosis and timely management.