■评估65岁及以上老年甲状腺乳头状癌(PTC)患者颈淋巴结转移的危险因素。
■在此回顾性分析中,我们纳入了328例年龄65岁及以上被诊断为PTC的老年患者.我们彻底检查了这些患者的临床特征。利用单变量和多变量逻辑回归分析,我们的目的是在65岁及以上的PTC患者这一特定人群中,确定导致中央和外侧淋巴结转移(CLNM/LLNM)风险的因素.
■在单变量分析中,CLNM与肿瘤大小显著相关,多焦点,双边性,和微钙化,而仅肿瘤大小≥1cm(OR=0.530,P=0.019,95%CI=0.311-0.900)和多灶性(OR=0.291,P<0.001,95%CI=0.148-0.574)在多变量分析中仍然是危险因素。LLNM被证实与男性相关(OR=0.454,P<0.020,95%CI=0.233-0.884),肿瘤大小≥1cm(OR=0.471,P=0.030,95%CI=0.239-0.928),年龄≥70岁(OR=0.489,P=0.032,95%CI=0.254-0.941),在多变量分析中,微钙化(OR=0.384,P=0.008,95%CI=0.189-0.781)。在患有CLNM的老年PTC患者中,男性(OR=0.350,P=0.021,95%CI=0.143-0.855),年龄≥70岁(OR=0.339,P=0.015,95%CI=0.142-0.810),在单变量和多变量分析中,双侧性(OR=0.320,P=0.012,95%CI=0.131-0.779)与合并LLNM密切相关。
■对于65岁及以上的老年PTC患者,肿瘤大小≥1cm和多灶性是CLNM的重要危险因素。同时,男性,肿瘤大小≥1cm,年龄≥70岁,微钙化是LLNM的关键预测因素。在已经诊断为CLNM的患者中,男性,年龄≥70岁,双边性会增加LLNM的风险。
UNASSIGNED: To assess the risk factors of cervical lymph node metastasis in elderly patients aged 65 years and older diagnosed with papillary thyroid cancer (PTC).
UNASSIGNED: In this retrospective analysis, we included a total of 328 elderly patients aged 65 years and older diagnosed with PTC. We thoroughly examined clinical features from these patients. Utilizing univariate and multivariate logistic regression analyses, we aimed to identify factors contributing to the risk of central and lateral lymph node metastasis (CLNM/LLNM) in this specific population of PTC patients aged 65 years and older.
UNASSIGNED: In the univariate analysis, CLNM was significantly associated with tumor size, multifocality, bilaterality, and microcalcification, while only tumor size ≥ 1cm (OR = 0.530, P = 0.019, 95% CI = 0.311 - 0.900) and multifocality (OR = 0.291, P < 0.001, 95% CI = 0.148 - 0.574) remained as risk factors in the multivariate analysis. LLNM was confirmed to be associated with male (OR = 0.454, P < 0.020, 95% CI = 0.233 - 0.884), tumor size ≥ 1cm (OR = 0.471, P = 0.030, 95% CI = 0.239 - 0.928), age ≥ 70 (OR = 0.489, P = 0.032, 95% CI = 0.254 - 0.941), and microcalcification (OR = 0.384, P = 0.008, 95% CI = 0.189 - 0.781) in the multivariate analysis. In elderly PTC patients with CLNM, male gender (OR = 0.350, P = 0.021, 95% CI = 0.143 - 0.855), age ≥ 70 (OR = 0.339, P = 0.015, 95% CI = 0.142 - 0.810), and bilaterality (OR = 0.320, P = 0.012, 95% CI = 0.131 - 0.779) were closely associated with concomitant LLNM in both univariate and multivariate analyses.
UNASSIGNED: For elderly PTC patients aged 65 and older, tumor size ≥ 1cm and multifocality are significant risk factors for CLNM. Meanwhile, male, tumor size ≥ 1cm, age ≥ 70, and microcalcification are crucial predictors for LLNM. In patients already diagnosed with CLNM, male, age ≥ 70, and bilaterality increase the risk of LLNM.