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Abstract：
UNASSIGNED: This study aimed to evaluate the efficacy of lateral lymph node dissection (LLND) for rectal cancer by comparing the local control in patients with and without pathological lateral lymph node metastasis (LLNM).
UNASSIGNED: We included 189 patients with rectal cancer who underwent total mesorectal excision and LLND at 13 institutions between 2017 and 2019. Patients with and without pathological LLNM were defined as the pLLNM (+) and (-) groups, respectively. Propensity score-matching helped to balance the basic characteristics of both groups. The incidences of local recurrence (LR) and lateral lymph node recurrence (LLNR) were compared between the groups.
UNASSIGNED: In the entire cohort, 39 of the 189 patients had pathological LLNM. The 3-year LR and LLNR rates were 18.3% and 4.0% (p = 0.01) and 7.7% and 3.3% (p = 0.22) in the pLLNM (+) and (-) groups, respectively. After propensity score matching, the data from 62 patients were analyzed. No significant differences in LR or LLNR were observed between both groups. The 3-year LR and LLNR rates were 16.4% and 9.8% (p = 0.46) and 9.7% and 9.8% (p = 0.99) in the pLLNM (+) and (-) groups, respectively.
UNASSIGNED: LLND would lead to comparable local control in the pLLNM (+) and (-) groups if the clinicopathological characteristics except for LLNM are similar.
UNASSIGNED: We included 189 patients with rectal cancer who underwent total mesorectal excision and LLND at 13 institutions between 2017 and 2019. Patients with and without pathological LLNM were defined as the pLLNM (+) and (-) groups, respectively. Propensity score-matching helped to balance the basic characteristics of both groups. The incidences of local recurrence (LR) and lateral lymph node recurrence (LLNR) were compared between the groups.
UNASSIGNED: In the entire cohort, 39 of the 189 patients had pathological LLNM. The 3-year LR and LLNR rates were 18.3% and 4.0% (p = 0.01) and 7.7% and 3.3% (p = 0.22) in the pLLNM (+) and (-) groups, respectively. After propensity score matching, the data from 62 patients were analyzed. No significant differences in LR or LLNR were observed between both groups. The 3-year LR and LLNR rates were 16.4% and 9.8% (p = 0.46) and 9.7% and 9.8% (p = 0.99) in the pLLNM (+) and (-) groups, respectively.
UNASSIGNED: LLND would lead to comparable local control in the pLLNM (+) and (-) groups if the clinicopathological characteristics except for LLNM are similar.
摘要：
■本研究旨在通过比较有和没有病理性外侧淋巴结转移（LLNM）的患者的局部对照来评估直肠癌外侧淋巴结清扫（LLND）的疗效。
■我们纳入了在2017年至2019年期间在13个机构接受全直肠系膜切除术和LLND的189例直肠癌患者。有和没有病理性LLNM的患者被定义为pLLNM（+）和（-）组，分别。倾向得分匹配有助于平衡两组的基本特征。比较两组患者局部复发(LR)和外侧淋巴结复发(LLNR)的发生率。
■在整个队列中，189例患者中有39例患有病理性LLNM。pLLNM(+)和(-)组的3年LR和LLNR率分别为18.3%和4.0%(p=0.01)和7.7%和3.3%(p=0.22)，分别。在倾向得分匹配后，对62例患者的数据进行了分析.两组间LR或LLNR无显著差异。pLLNM(+)和(-)组的3年LR和LLNR分别为16.4%和9.8%(p=0.46)和9.7%和9.8%(p=0.99)，分别。
■如果除LLNM外的临床病理特征相似，则在pLLNM（）和（-）组中，LLND将导致相当的局部控制。
■我们纳入了在2017年至2019年期间在13个机构接受全直肠系膜切除术和LLND的189例直肠癌患者。有和没有病理性LLNM的患者被定义为pLLNM（+）和（-）组，分别。倾向得分匹配有助于平衡两组的基本特征。比较两组患者局部复发(LR)和外侧淋巴结复发(LLNR)的发生率。
■在整个队列中，189例患者中有39例患有病理性LLNM。pLLNM(+)和(-)组的3年LR和LLNR率分别为18.3%和4.0%(p=0.01)和7.7%和3.3%(p=0.22)，分别。在倾向得分匹配后，对62例患者的数据进行了分析.两组间LR或LLNR无显著差异。pLLNM(+)和(-)组的3年LR和LLNR分别为16.4%和9.8%(p=0.46)和9.7%和9.8%(p=0.99)，分别。
■如果除LLNM外的临床病理特征相似，则在pLLNM（）和（-）组中，LLND将导致相当的局部控制。
