■我们对随机临床试验进行了荟萃分析,评估了与其他静脉注射铁相比,羧基麦芽糖铁治疗在改善孕妇血红蛋白和血清铁蛋白方面的临床效果。我们还评估了羧基麦芽糖铁的安全性与其他静脉注射铁。
■EMBASE,PubMed,和WebofScience搜索了与孕妇中羧基麦芽糖铁相关的试验,2005年至2021年出版。我们还回顾了谷歌学者的文章。关键词\"羧基麦芽糖铁,\"\"FCM,静脉注射,\"\"随机化,\"\"怀孕,“\”生活质量,“和”新生儿结局“用于检索文献。搜索仅限于孕妇。
■扫描了与妊娠中羧基麦芽糖铁相关的研究。观察性研究,评论文章,病例报告被排除.涉及羧基麦芽糖铁和其他静脉铁制剂的孕妇随机研究入围。在256项研究中,选择9项随机对照试验.
■两名评审员独立地从9项选定的试验中提取数据。
■羧基麦芽糖铁治疗后血红蛋白增加的最终效应大小显着。蔗糖铁/聚麦芽糖铁(标准平均差0.89g/dl[95%置信区间0.27,1.51])。治疗后铁蛋白增加的最终效果大小对于羧基麦芽糖铁和蔗糖铁/聚麦芽糖铁(标准平均差22.53µg/L[-7.26,52.33])。没有严重不良事件的报告与铁羧基麦芽糖或其他静脉铁。
■在增加血红蛋白和铁蛋白水平治疗孕妇缺铁性贫血方面,羧基麦芽糖铁表现出比其他静脉注射铁更好的疗效。
UNASSIGNED: We conducted a meta-analysis of randomized clinical trials evaluating the clinical effects of ferric carboxymaltose therapy compared to other intravenous iron in improving hemoglobin and serum ferritin in pregnant women. We also assessed the safety of ferric carboxymaltose vs. other intravenous iron.
UNASSIGNED: EMBASE, PubMed, and Web of Science were searched for trials related to ferric carboxymaltose in pregnant women, published between 2005 and 2021. We also reviewed articles from google scholar. The keywords \"ferric carboxymaltose,\" \"FCM,\" \"intravenous,\" \"randomized,\" \"pregnancy,\" \"quality of life,\" and \"neonatal outcomes\" were used to search the literature. The search was limited to pregnant women.
UNASSIGNED: Studies related to ferric carboxymaltose in pregnancy were scanned. Observational studies, review articles, and case reports were excluded. Randomized studies in pregnant women involving ferric carboxymaltose and other intravenous iron formulations were shortlisted. Of 256 studies, nine randomized control trials were selected.
UNASSIGNED: Two reviewers independently extracted data from nine selected trials.
UNASSIGNED: The final effect size for increase in hemoglobin after treatment was significant for ferric carboxymaltose vs. iron sucrose/iron polymaltose (standard mean difference 0.89g/dl [95% confidence interval 0.27,1.51]). The final effect size for the increase in ferritin after treatment was more for ferric carboxymaltose vs. iron sucrose/iron polymaltose (standard mean difference 22.53µg/L [-7.26, 52.33]). No serious adverse events were reported with ferric carboxymaltose or other intravenous iron.
UNASSIGNED: Ferric carboxymaltose demonstrated better efficacy than other intravenous iron in increasing hemoglobin and ferritin levels in treating iron deficiency anemia in pregnant women.