investigation

调查
  • 文章类型: Journal Article
    背景:急性健康急性护理中的种族不平等尚未得到很好的研究。我们研究了参与者种族如何影响未选择的胃肠道(GI)疾病患者的急诊治疗结果。
    方法:描述性,莱斯特大学医院急诊科参与者匿名患者水平数据的回顾性队列分析,从2018年1月1日至2021年12月31日,我们接受了胃肠道疾病诊断.感兴趣的主要接触是自我报告的种族,研究的两个结局是入院和患者是否接受了临床调查.混杂变量,包括性别和年龄,在分析中调整了剥夺指数和疾病敏锐度.卡方检验和Kruskal-Wallis检验用于检查结果指标和协变量之间的种族差异。多变量逻辑回归用于检查种族和结果测量之间的关联。
    结果:在34,337人中,中位年龄43岁,被确定为患有胃肠道疾病的急诊室,68.6%是白人。少数民族患者明显比白人患者年轻。所有种族的多急诊科出勤率相似(总体为18.3%)。白人患者的调查中位数最高(6,IQR3-7),而来自混合族裔的人最低(2,IQR0-6)。调整后的年龄,性别,出席年,多重剥夺和疾病敏锐度指数,与白种人患者相比,所有少数族裔患者接受现症调查的可能性仍然显著较低(亚裔:aOR0.80,95%CI0.74~0.87;黑人:0.67,95%CI0.58~0.79;混合:0.71,95%CI0.59~0.86;其他:0.79,95%CI0.67~0.93;全部p<0.0001).同样,调整后,少数族裔患者入院的可能性也明显较小(亚裔:aOR0.63,95%CI0.60-0.67;黑人:0.60,95%CI0.54-0.68;混合:0.60,95%CI0.51-0.71;其他:0.61,95%CI0.54-0.69;全部p<0.0001).
    结论:本研究观察到不同种族胃肠道疾病患者在使用模式和急性护理结果方面的显著差异。在对混杂因素以及剥夺和疾病敏锐度的测量进行调整后,这些差异仍然存在,并且表明与白人患者相比,少数民族个体不太可能接受调查或入院。
    BACKGROUND: Ethnic inequalities in acute health acute care are not well researched. We examined how attendee ethnicity influenced outcomes of emergency care in unselected patients presenting with a gastrointestinal (GI) disorder.
    METHODS: A descriptive, retrospective cohort analysis of anonymised patient level data for University Hospitals of Leicester emergency department attendees, from 1 January 2018 to 31 December 2021, receiving a diagnosis of a GI disorder was performed. The primary exposure of interest was self-reported ethnicity, and the two outcomes studied were admission to hospital and whether patients underwent clinical investigations. Confounding variables including sex and age, deprivation index and illness acuity were adjusted for in the analysis. Chi-squared and Kruskal-Wallis tests were used to examine ethnic differences across outcome measures and covariates. Multivariable logistic regression was used to examine associations between ethnicity and outcome measures.
    RESULTS: Of 34,337 individuals, median age 43 years, identified as attending the ED with a GI disorder, 68.6% were White. Minority ethnic patients were significantly younger than White patients. Multiple emergency department attendance rates were similar for all ethnicities (overall 18.3%). White patients had the highest median number of investigations (6, IQR 3-7), whereas those from mixed ethnic groups had the lowest (2, IQR 0-6). After adjustment for age, sex, year of attendance, index of multiple deprivation and illness acuity, all ethnic minority groups remained significantly less likely to be investigated for their presenting illness compared to White patients (Asian: aOR 0.80, 95% CI 0.74-0.87; Black: 0.67, 95% CI 0.58-0.79; mixed: 0.71, 95% CI 0.59-0.86; other: 0.79, 95% CI 0.67-0.93; p < 0.0001 for all). Similarly, after adjustment, minority ethnic attendees were also significantly less likely to be admitted to hospital (Asian: aOR 0.63, 95% CI 0.60-0.67; Black: 0.60, 95% CI 0.54-0.68; mixed: 0.60, 95% CI 0.51-0.71; other: 0.61, 95% CI 0.54-0.69; p < 0.0001 for all).
    CONCLUSIONS: Significant differences in usage patterns and disparities in acute care outcomes for patients of different ethnicities with GI disorders were observed in this study. These differences persisted after adjustment both for confounders and for measures of deprivation and illness acuity and indicate that minority ethnic individuals are less likely to be investigated or admitted to hospital than White patients.
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  • 文章类型: Journal Article
    背景:饮用水污染后的水传播疾病暴发(WGDO)仍然是公共卫生问题。
    方法:本研究旨在评估希腊WGDO的通知和调查中的发生情况并确定差距。检索并总结了2004-2023年的数据。
    结果:确定了35次暴发,记录了6128例病例。从第一批病例的发病日期到报告的中位时间为7天(范围:1-26天)。当局在30起(85.7%)疫情中得到了医疗保健服务的通知,在5起(14.3%)病例中得到了媒体的通知。使用的调查方法多种多样。对9次(25.7%)疫情进行了分析研究,对27次(77.1%)的临床样本进行了检测。在三次(11.1%)疫情中,临床样本同时检测多种细菌,病毒,和寄生虫。在19次(54.3%)暴发(氯化后3次)中收集了水样,平均时滞为5天(范围:1-20天)。在20例(57.1%)疫情中发现了临床样本中的病原体,在1(6.25%)中,在临床和水样中均分离出相同的微生物。
    结论:报告的延迟和调查的异质性表明,应加强对WGDO和应对措施的监测,和操作程序应该标准化。
    BACKGROUND: waterborne disease outbreaks (WGDOs) following the contamination of drinking water remain a public health concern.
    METHODS: The current study aims to assess the occurrence and identify gaps in the notification and investigation of WGDOs in Greece. Data for 2004-2023 were retrieved and summarized.
    RESULTS: Thirty-five outbreaks with 6128 recorded cases were identified. The median time from the date of onset in the first cases to reporting was 7 days (range: 1-26 days). Authorities were informed by health care services in thirty (85.7%) outbreaks and by the media in five (14.3%). The investigation methods used varied. An analytical study was conducted in nine (25.7%) outbreaks and the testing of clinical samples in twenty-seven (77.1%). In three (11.1%) outbreaks, clinical samples were simultaneously tested for multiple bacteria, viruses, and parasites. Water samples were collected in nineteen (54.3%) outbreaks (in three after chlorination) with a mean time lag of 5 days (range: 1-20 days) from the first cases. A pathogen in clinical samples was identified in 20 (57.1%) outbreaks and, in 1 (6.25%), the same microorganism was isolated in both clinical and water samples.
    CONCLUSIONS: delays in reporting and the heterogeneity of investigations depict that the surveillance of WGDOs and response practices should be strengthened, and operational procedures should be standardised.
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  • 文章类型: Editorial
    这篇社论对最近发表在《世界临床病例杂志》上的一篇文章进行了分析。川崎病(KD)是一种以发烧为特征的众所周知的小儿血管炎,皮疹,结膜炎,口腔粘膜改变,四肢肿胀.这篇社论旨在深入研究KD和腹痛之间的复杂关系,从最近的研究结果中汲取见解,为未来的调查提供全面的理解和潜在的途径。
    This editorial presents an analysis of an article recently published in the World Journal of Clinical Cases. Kawasaki disease (KD) is a well-known pediatric vasculitis characterized by fever, rash, conjunctivitis, oral mucosal changes, and swelling of the extremities. This editorial aims to delve into the intricate relationship between KD and abdominal pain, drawing insights from recent research findings to provide a comprehensive understanding and potential avenues for future investigation.
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  • 文章类型: Journal Article
    目的:探讨58家医院在131I治疗前照顾分化型甲状腺癌患者的医务人员实施低碘饮食的情况。并为制定低碘饮食指南提供有价值的见解。
    方法:采用便利抽样方法,对58所三级医院的163名在核医学科室工作的医务人员进行问卷调查。
    结果:关于治疗前低碘饮食的持续时间,医务人员的建议如下:58.28%建议2-4周,31.29%建议超过4周,9.2%的人选择了7-13天,和1.23%青睐不到1周。关于恢复正常饮食的时机,受访者的建议范围从治疗后立即(1.84%)到治疗后3个月(8.58%),中间推荐2小时(8.58%),24-48小时(14.11%),出院后(12.26%),和1个月(42.94%)。此外,接受调查的医务人员一致建议放弃海鲜,90.8%的人也建议不要食用碘盐,91.41%建议避免使用含碘药物,71.17%建议对中度高碘食物谨慎。值得注意的是,75.46%的医务人员评估了患者对低碘饮食的依从性。当患者未能坚持饮食准备时,33.74%的医护人员选择继续治疗。在指导来源方面,96.93%的受访者依赖相关指引,66.26%引用了文献,49.69%的人借鉴了他们的临床经验。住院期间,58.28%的医务人员继续指导患者低碘饮食,而出院后只有8.59%提供了此类指导。值得注意的是,只有20.25%的员工考虑咨询营养部门。
    结论:这项研究强调了低碘饮食的持续时间和选择标准的巨大差异,这与缺乏标准化评估有关。因此,迫切需要进一步的研究来建立详细的,实用,可访问,全面,和可靠的低碘饮食实施方案。
    OBJECTIVE: To explore the implementation of low-iodine diets by medical staff caring for patients with differentiated thyroid carcinoma prior to 131I therapy across 58 hospitals, and offer valuable insights for the development of guidelines on low-iodine diets.
    METHODS: Convenience sampling was utilized to conduct a survey among 163 medical staff members working in nuclear medicine departments across 58 tertiary hospitals using a self-designed questionnaire.
    RESULTS: Concerning the duration of the low-iodine diet prior to treatment, the medical staff\'s recommendations were as follows: 58.28% suggested 2-4 weeks, 31.29% recommended more than 4 weeks, 9.2% opted for 7-13 days, and 1.23% favored less than 1 week. Regarding the timing of resuming a normal diet, the respondents\' recommendations ranged from immediately after treatment (1.84%) to 3 months post-treatment (8.58%), with intermediate recommendations of 2 h (8.58%), 24-48 h (14.11%), post-discharge (12.26%), and 1 month (42.94%). Furthermore, the surveyed medical staff unanimously recommended abstaining from seafood, with 90.8% also advising against the consumption of iodized salt, 91.41% recommending avoidance of iodine-containing medications, and 71.17% advising caution with moderately high-iodine foods. Notably, 75.46% of the medical staff evaluated patient compliance with the low-iodine diet. When patients failed to adhere to the diet preparation, 33.74% of healthcare workers chose to proceed with treatment. In terms of guidance sources, 96.93% of respondents relied on relevant guidelines, 66.26% referred to the literature, and 49.69% drew upon their clinical experience. During hospitalization, 58.28% of the medical staff continued to guide patients on the low-iodine diet, while only 8.59% provided such guidance after discharge. Notably, only 20.25% of the staff considered consulting the nutrition department.
    CONCLUSIONS: This study underscored substantial variations in the duration and selection criteria for low-iodine diets, which were linked to a scarcity of standardized evaluations. Consequently, there is an urgent need for further research to establish detailed, practical, accessible, comprehensive, and dependable implementation programs for low-iodine diets.
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  • 文章类型: Journal Article
    ShurijoSeiden起火,或者舒里霍城堡的主厅,那霸-市,冲绳,10月30日上午,日本2019.大火导致8座建筑物和许多重要的冲绳文化资产损失。原始的Shurijo城堡在很多年前被摧毁,并建造和重建了一个复制品,以尽可能接近原始建筑。复制品主要由木材(Chamaecypristaiwanensis)制成。据报道,火灾期间有Firebrands。在这项研究中,收集并分析了Shurijo城堡的火把。将数据与其他调查以及实验数据进行了比较。
    A fire started in Shurijo Seiden, or the main hall of Shurijo Castle, Naha-city, Okinawa, Japan on the morning of October 30th, 2019. The fire resulted in loss of 8 structures and many important Okinawan cultural assets. The original Shurijo Castle was destroyed many years ago and a replica was constructed and rebuilt to be as close as possible to the original building. The replica was fabricated mainly from wood (Chamaecyparis taiwanensis). Firebrands were reported during the fire. In this study, firebrands from Shurijo Castle was collected and analyzed. The data was compared with those from other investigation as well as experimental data.
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    文章类型: Journal Article
    在2023年9月的最后一周,在菲律宾武装部队(AFP)卫生服务教育和培训中心的学生中观察到流感样疾病激增,该中心247名军事学生中有48名(27名男性和21名女性;年龄:平均33岁,范围27-41)出现呼吸道症状。在2023年9月25日至10月10日之间,对所有48名有症状的学生进行了实时逆转录聚合酶链反应和测序,以评估流感和SARS-CoV-2。13名(27%)学生仅被发现甲型/H3流感呈阳性,仅SARS-CoV-2为6(13%),4例(8%)同时感染了A/H3流感和SARS-CoV-2。17种甲型/H3N2流感病毒属于同一进化枝,3C.2a1b.2a.2a.3a,和4个SARSCoV-2序列属于JE1.1谱系,表明两者的共同来源爆发。A/H3N2流感病毒与2023年的疫苗株属于不同的进化枝(3C.2a1b.2a2a)。只有4名学生在2023年接种了流感疫苗。作为回应,法新社卫生部长于2023年10月19日向所有军事卫生机构发布了一份备忘录,规定接种流感疫苗是所有教育和培训中心招收学生的先决条件,以及实施非药物干预措施以及对表现出流感样疾病的学生进行早期通知和测试。
    In the last week of September 2023, a surge of influenza-like illness was observed among students of the Armed Forces of the Philippines (AFP) Health Service Education and Training Center, where 48 (27 males and 21 females; age in years: mean 33, range 27-41) of 247 military students at the Center presented with respiratory symptoms. Between September 25 and October 10, 2023, all 48 symptomatic students were evaluated with real-time reverse transcription polymerase chain reaction and sequencing for both influenza and SARS-CoV-2. Thirteen (27%) students were found positive for influenza A/H3 only, 6 (13%) for SARS-CoV-2 only, and 4 (8%) were co-infected with influenza A/H3 and SARS-CoV-2. Seventeen influenza A/ H3N2 viruses belonged to the same clade, 3C.2a1b.2a.2a.3a, and 4 SARSCoV-2 sequences belonged to the JE1.1 lineage, indicating a common source outbreak for both. The influenza A/H3N2 circulating virus belonged to a different clade than the vaccine strain for 2023 (3C.2a1b.2a.2a). Only 4 students had received the influenza vaccine for 2023. In response, the AFP Surgeon General issued a memorandum to all military health institutions on October 19, 2023 that mandated influenza vaccination as a prerequisite for enrollment of students at all education and training centers, along with implementation of non-pharmaceutical interventions and early notification and testing of students exhibiting influenza-like-illness.
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  • 文章类型: Journal Article
    快速的经济增长,城市化,埃塞俄比亚的工业化导致需要建立各种基础设施和许多使用不同类型材料的住宅建筑。钢筋是埃塞俄比亚消耗最多的建筑材料之一。埃塞俄比亚对钢筋的需求满足了当地生产和国际市场。然而,大多数人对没有正当理由使用当地产品缺乏信任。这项调查工作是为了评估当地生产的钢筋在埃塞俄比亚强制性标准(CES)方面的性能,以建立对不同项目承包商和顾问的信任。强制性埃塞俄比亚标准(CES)是在混凝土和混凝土产品技术委员会的指导下制定并由埃塞俄比亚标准局(ESA)发布的埃塞俄比亚标准。对从四个不同工厂收集的不同直径的B400BWR和B500BWR级钢筋进行了实验工作。收集的样品根据其屈服强度进行了调查,极限抗拉强度,伸长率,硬度,化学成分,和产品的微观结构形成。屈服强度,极限抗拉强度,根据2000KN万能试验机(UTM)获得的拉伸测试结果,分析了钢筋的伸长率,并使用火花发射光谱分析仪进行化学成分分析。使用维氏硬度测试仪以3kgf和15s的停留时间在沿着钢筋横截面的0.5mm间隙处进行显微硬度测试。使用EDX扫描电子显微镜(SEM)和光学显微镜对钢筋的横截面进行不同的放大倍数和分辨率的微观结构分析。从测试样品中,一个样品从B400BWR失败,以实现由CES101,2017规定的400MPa的最小所需屈服强度。B500BWR样品满足标准规定的所有要求,即使超过最小要求的增量高达41%。
    The fast economic growth, urbanization, and industrialization of Ethiopia led to the requirement for the establishment of various infrastructures and many residential building constructions consuming different types of materials. Reinforced steel bar is one of the most consumed construction materials in Ethiopia. The demand for reinforced steel bars in Ethiopia is satisfied by the local production and international market. However, most people lack trust to the use local products without justified reasons. This investigation work was done to evaluate the performance of the locally produced rebar concerning the Compulsory Ethiopian Standard (CES) to develop trust in contractors and consultants of different projects. A Compulsory Ethiopian Standard (CES) is an Ethiopian standard that has been prepared under the direction of the Technical Committee for Concrete and Concrete Products and published by the Ethiopian Standards Agency (ESA). Experimental works were done on rebar of grades B400BWR and B500BWR with different diameters collected from four different factories. The collected samples were investigated based on their yield strength, ultimate tensile strength, elongation, hardness, chemical composition, and microstructure formation of the product. The yield strength, ultimate tensile strength, and elongation of the rebar were analyzed based on the tension test results obtained from the 2000 KN Universal Testing Machine (UTM), and the chemical composition analysis was done using the Spark Emission Spectrometer Analyzer. The micro-hardness test was done using the Vickers Hardness Tester with 3kgf and 15-s dwell time at a 0.5 mm gap along the cross-section of the rebar. Microstructure analysis is done using EDX scanning electron microscope (SEM) and optical microscopy with different magnifications and resolutions on the cross-section of the rebar. From the tested samples one sample failed from B400BWR to achieve the minimum required yield strength of 400 MPa stated by CES 101, 2017. Samples of B500BWR satisfy all the requirements stated by the standard even if there is an increment up to 41 % beyond the minimum requirement.
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  • 文章类型: Systematic Review
    耳聋对视觉注意力的影响在先前的研究中已经被广泛讨论。人们注意到,以前研究的不足和优势可以归因于注意力的时间或空间方面,以及发展和临床特征的变化。视觉注意力分为三个网络:定向(外源和内源),警报(阶段性和补品),和执行控制。这项研究旨在提供支持这一假设的新神经科学证据。本文对过去15年中有关聋人视觉注意力的国际文献进行了系统的回顾。最终审查包括24篇文章。发现定向网络的功能在聋人和儿童中得到增强,主要在没有人工耳蜗的原生签名者中观察到,虽然内源性定向仅在儿童的凝视线索中观察到,在成年人中没有发现差异。有关警报和执行功能的结果取决于所使用的临床特征和范例。讨论了对聋人视觉注意的未来研究的意义。
    The impact of deafness on visual attention has been widely discussed in previous research. It has been noted that deficiencies and strengths of previous research can be attributed to temporal or spatial aspects of attention, as well as variations in development and clinical characteristics. Visual attention is categorized into three networks: orienting (exogenous and endogenous), alerting (phasic and tonic), and executive control. This study aims to contribute new neuroscientific evidence supporting this hypothesis. This paper presents a systematic review of the international literature from the past 15 years focused on visual attention in the deaf population. The final review included 24 articles. The function of the orienting network is found to be enhanced in deaf adults and children, primarily observed in native signers without cochlear implants, while endogenous orienting is observed only in the context of gaze cues in children, with no differences found in adults. Results regarding alerting and executive function vary depending on clinical characteristics and paradigms used. Implications for future research on visual attention in the deaf population are discussed.
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  • 文章类型: Journal Article
    粘膜IgA在宿主对呼吸道病毒的免疫中起着至关重要的作用。最近的研究表明,它有可能减轻严重急性呼吸道综合症冠状病毒2(SARS-CoV-2)Omicron变体的传播。然而,在2022年冬季冠状病毒病2019(COVID-19)大流行浪潮之后,尚未进行全面的基于人群的分析,以检查粘膜IgA水平.
    在我们涉及3,421名参与者的研究中,我们记录了SARS-CoV-2感染后的IgA反应。相当比例的个体的IgA水平持续升高超过6个月。在经历无症状再感染的先前感染的个体中也观察到这些水平,表明IgA抗体的活跃产生。Further,多次接种疫苗或出现严重症状的个体在康复后倾向于显示IgA水平升高.
    鼻粘膜中的IgA对于防御SARS-CoV-2感染至关重要。这些见解可以增强我们对感染后免疫反应的认识,并为疾病预防和控制策略提供了一定的参考价值。
    UNASSIGNED: Mucosal IgA plays a crucial role in host immunity against respiratory viruses. Recent studies suggest that it has the potential to mitigate the transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant. However, a comprehensive population-based analysis examining mucosal IgA levels following the winter 2022 wave of the coronavirus disease 2019 (COVID-19) pandemic is yet to be conducted.
    UNASSIGNED: In our study involving 3,421 participants, we documented IgA responses subsequent to SARS-CoV-2 infection. A significant proportion of individuals sustained increased levels of IgA for over six months. These levels were also observed in individuals with prior infections who underwent asymptomatic reinfections, indicating an active production of IgA antibodies. Further, individuals with multiple vaccinations or severe symptoms tended to display elevated IgA levels after recovery.
    UNASSIGNED: IgA in the nasal mucosa is crucial for defense against SARS-CoV-2 infection. These insights can enhance our knowledge of immune responses following infection and have provided certain reference values for disease prevention and control strategies.
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  • 文章类型: Case Reports
    X学校的管理人员向公共卫生当局通报了发烧和咳嗽的爆发,Kozhikode区,喀拉拉邦,2020年1月1日。我们进行了疫情调查以确认诊断,用时间描述病人,地点,和人,并提出适当的建议。
    我们将可能的流感病例定义为X学校的任何学生或教职员工,Kozhikode区在2019年12月30日至2020年1月14日之间发烧和咳嗽。我们在学校进行了积极的病例搜索和接触者追踪。我们使用Epicurve描述了症状发作日期的病例,在他们的教室里绘制案例,按年龄计算攻击率,和性别。
    我们确定了270例流感病例;其中,264人(98%)是学生,6名(2%)是员工。总体攻击率为36%。学生的攻击率(39%)高于教职员工(12%,6/49,P<0.0003)。10E班学生的攻击率较高(90%,37/41)和10A类(80%,33/41),索引病例在症状阶段与学生接触。
    学生和教职员工爆发甲型H1N1流感,主要影响第十师。学校和卫生当局实施了几项干预措施来限制疫情爆发,包括对学生进行个人卫生方面的培训。我们建议进行流感监测,保持足够的长凳间距,自我卫生习惯,教室通风。
    UNASSIGNED: An outbreak of fever and cough was notified to public health authorities by the management of school X among their students, Kozhikode district, Kerala, on Jan 1, 2020. We conducted an outbreak investigation to confirm the diagnosis, describe the case patients by time, place, and person, and propose appropriate recommendations.
    UNASSIGNED: We defined a probable case of influenza as any student or staff of school X, Kozhikode district with a fever and cough between Dec 30, 2019, and Jan 14, 2020. We conducted an active case search and contact tracing in the school. We described the cases by date of symptom onset using an Epicurve, plotted cases by their classroom, and calculated the attack rate by age, and gender.
    UNASSIGNED: We identified 270 cases of influenza; among them, 264 (98%) were students, and 6 (2%) were the staff. The overall attack rate was 36%. The attack rate was higher among the students (39%) than the staff (12%, 6/49, P < 0.0003). The attack rate was higher among students of class 10E (90%, 37/41) and class 10A (80%, 33/41), where the index case had contact with the students during the symptomatic phase.
    UNASSIGNED: An outbreak of influenza A (H1N1) occurred among students and staff, predominantly affecting the 10th division. School and health authorities implemented several interventions to limit the outbreak, including training students on personal hygiene. We recommended conducting surveillance of influenza, maintaining adequate spacing of benches, self-hygiene practices, and classroom ventilation.
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