背景:多囊卵巢综合征(PCOS),育龄妇女常见的内分泌紊乱,与慢性低度炎症和代谢紊乱密切相关。在PCOS小鼠中,膳食菊粉已被证明可以调节肠道菌群和炎症。然而,膳食菊糖在临床PCOS中的疗效尚不清楚.
目的:分析菊糖治疗3个月后肥胖多囊卵巢综合征(PCOS)患者的肠道菌群和相关代谢指标。
方法:分析接受菊糖治疗3个月后健康对照组和肥胖多囊卵巢综合征患者的肠道菌群和相关代谢指标。
结果:结果表明,膳食菊粉改善了性激素紊乱,肥胖PCOS女性的BMI和WHR水平降低。此外,菊粉干预降低血浆TNF-α,IL-1β,IL-6和MCP-1水平。菊粉干预增加了放线菌的丰度,镰刀菌,落叶螺旋体,和双歧杆菌,以及降低F/B比率和蛋白质的丰度,Sutterilla,和肠杆菌。相关分析表明,血浆炎症因子之间存在很强的相关性,性类固醇激素,以及患者的肠道菌群。
结论:膳食菊粉可能通过肠道菌群-炎症-类固醇激素途径改善肥胖PCOS女性疾病。
背景:ChiCTR-IOR-17012281。
BACKGROUND: Polycystic ovary syndrome (PCOS), a common endocrine disorder in women of reproductive age, is closely associated with chronic low-grade inflammation and metabolic disturbances. In PCOS mice, dietary
inulin has been demonstrated to regulate intestinal flora and inflammation. However, the efficacy of dietary
inulin in clinical PCOS remains unclear.
OBJECTIVE: The intestinal flora and related metabolic indexes of obese patients with polycystic ovary syndrome (PCOS) after 3 months of
inulin treatment were analyzed.
METHODS: To analyze the intestinal flora and related metabolic indexes in healthy controls and obese patients with polycystic ovary syndrome after 3 months of inulin treatment.
RESULTS: The results showed that dietary
inulin improved sex hormone disorders, reduced BMI and WHR levels in obese women with PCOS. In addition, the
inulin intervention reduced plasma TNF-α, IL-1β, IL-6, and MCP-1levels. Inulin intervention increased the abundance of Actinobacteria, Fusobacteria, Lachnospira, and Bifidobacterium, as well as decreased the ratio of F/B and the abundance of proteobacteria, Sutterella, and Enterobacter. Correlation analyses showed a strong relationship among plasma inflammatory factors, sex steroid hormones, and the intestinal flora of patients.
CONCLUSIONS: Dietary inulin may improve obese PCOS women disease through the gut flora-inflammation-steroid hormone pathway.
BACKGROUND: ChiCTR-IOR-17012281.