■由超声引导的体积调制电弧疗法(VMAT)是一种新颖的放射治疗技术,可在图像引导下促进肿瘤靶区的勾画,提高放射治疗的精度,最大限度地保护周围组织。
■本文的目的是探讨超声引导下VMAT对宫颈癌患者的疗效及其对放疗剂量和预后的影响。
一项回顾性分析涵盖了2019年4月至2021年4月期间入住我们医疗机构的128例宫颈癌患者。将患者分为观察队列和对照组,取决于入院后治疗方式的变化。对照组行常规放疗,观察组接受超声引导下的VMAT。临床疗效,平均辐射剂量(在放射治疗靶区,直肠,和膀胱),治疗期间放疗相关的毒性,比较两组患者1年生存率。此外,治疗前后血清鳞状细胞癌抗原(SCC-Ag)水平的变化,癌胚抗原(CEA),和碳水化合物抗原724(CA724)进行评估。
■与对照组(64.52%)相比,观察队列的综合有效率明显更高(80.30%)。观察组平均辐射暴露量较低,治疗后CEA浓度降低,SCC-Ag,CA724放射治疗不良反应的总体发生率也有所下降。观察组1年生存率(90.48%)高于对照组(73.33%)。当将观察队列与对照组进行比较时,Kaplan-Meier生存分析显示1年生存率显著增高(Log-Rank=6.530,P=0.011)。
■VMAT在超声引导下对宫颈癌患者的短期和长期治疗效果良好。它还导致血清CEA的改善,SCC-Ag,和CA724级别,以及减少对放射治疗靶区的平均放射剂量,直肠,和膀胱。这种方法值得临床医生在临床实践中的关注。
UNASSIGNED: Volumetric modulated arc therapy (VMAT) guided by ultrasound is a novel radiation therapy technique that facilitates the delineation of the tumor target area under image guidance, enhancing the precision of radiation therapy and maximizing the protection of surrounding tissues.
UNASSIGNED: The objective of this paper is to investigate the effectiveness of VMAT under ultrasonic guidance for cervical cancer patients and its impact on radiotherapy dosage and prognosis.
UNASSIGNED: A retrospective analysis encompassed 128 instances of cervical cancer patients who were admitted to our medical facility between April 2019 and April 2021. The patients were categorized into an observation cohort and a control cohort, depending on variations in treatment modalities post-admission. The control group underwent conventional radiotherapy, whereas the observation group received VMAT guided by ultrasound. Clinical efficacy, average radiation dosages (in the radiotherapy target area, rectum, and bladder), radiotherapy-related toxicities during treatment, and one-year survival rates were compared between the two groups. Additionally, variances in pre- and post-treatment serum levels of squamous cell carcinoma antigen (SCC-Ag), carcinoembryonic antigen (CEA), and carbohydrate antigen 724 (CA724) were subjected to assessment.
UNASSIGNED: When compared to the control group (64.52%), the observation cohort\'s comprehensive effectiveness rate was considerably greater (80.30%). The observation group saw lower average radiation exposures and a reduction in the post-treatment concentrations of CEA, SCC-Ag, and CA724. The overall incidence of adverse effects from radiation treatment also declined. The observation group had a greater one-year survival rate (90.48%) than the control group (73.33%). When comparing the observation cohort to the control group, Kaplan-Meier survival analysis showed a significantly higher one-year survival rate (Log-Rank = 6.530, P= 0.011).
UNASSIGNED: VMAT guided by ultrasound for patients with cervical cancer demonstrates promising short- and long-term treatment outcomes. It also leads to improvements in serum CEA, SCC-Ag, and CA724 levels, as well as reductions in the average radiation dosages to the radiotherapy target area, rectum, and bladder. This approach warrants attention from clinicians in clinical practice.