Abstract：
OBJECTIVE: Heterotopic ossification (HO) is a common complication following total hip arthroplasty. Various prophylactic treatments have been proposed, including radiotherapy (RT). This review summarizes the evidence from meta-analyses on the efficacy of RT in preventing hip HO.
METHODS: A literature search was conducted on PubMed. The quality of the meta-analyses was assessed using the AMSTAR-2 tool.
RESULTS: Seven meta-analyses were included. One meta-analysis reported a significant reduction in HO occurrence after RT compared to the control group. Comparing RT and non-steroidal anti-inflammatory drugs, one and two meta-analyses showed significantly greater efficacy of RT in preventing severe HO and better outcomes in patients receiving drugs, respectively. Regarding RT settings, the postoperative and preoperative RT were each supported by one meta-analysis. Furthermore, two meta-analyses showed an advantage of multi-fractionated RT over single fraction RT. The overall confidence rate of the meta-analyses was moderate, low, and critically low in one, three, and three meta-analyses, respectively.
CONCLUSIONS: RT is a confirmed prophylactic intervention for HO. However, the precise optimization of timing, dosage, and fractionation requires elucidation. Future research should focus on the development of predictive models through large-scale data collection and advanced analytics to refine individualized treatment strategies and assess RT comparative effectiveness with drugs.
METHODS: A literature search was conducted on PubMed. The quality of the meta-analyses was assessed using the AMSTAR-2 tool.
RESULTS: Seven meta-analyses were included. One meta-analysis reported a significant reduction in HO occurrence after RT compared to the control group. Comparing RT and non-steroidal anti-inflammatory drugs, one and two meta-analyses showed significantly greater efficacy of RT in preventing severe HO and better outcomes in patients receiving drugs, respectively. Regarding RT settings, the postoperative and preoperative RT were each supported by one meta-analysis. Furthermore, two meta-analyses showed an advantage of multi-fractionated RT over single fraction RT. The overall confidence rate of the meta-analyses was moderate, low, and critically low in one, three, and three meta-analyses, respectively.
CONCLUSIONS: RT is a confirmed prophylactic intervention for HO. However, the precise optimization of timing, dosage, and fractionation requires elucidation. Future research should focus on the development of predictive models through large-scale data collection and advanced analytics to refine individualized treatment strategies and assess RT comparative effectiveness with drugs.
摘要：
目的：异位骨化（HO）是全髋关节置换术后常见的并发症。已经提出了各种预防性治疗,包括放疗（RT）。这篇综述总结了RT预防髋关节HO疗效的荟萃分析证据。
方法：在PubMed上进行了文献检索。使用AMSTAR-2工具评估荟萃分析的质量。
结果：纳入7项meta分析。一项荟萃分析报告，与对照组相比，RT后HO发生率显着降低。比较RT和非甾体抗炎药，一项和两项荟萃分析显示，RT在预防重度HO方面的疗效明显更高，在接受药物治疗的患者中效果更好，分别。关于RT设置，术后和术前RT均得到一项荟萃分析的支持.此外，两项荟萃分析显示，多级RT优于单级RT。荟萃分析的总体置信度是中等的，低,在一个人中非常低，三,和三个荟萃分析，分别。
结论：RT是一种经证实的HO预防性干预措施。然而,定时的精确优化，剂量,分馏需要阐明。未来的研究应侧重于通过大规模数据收集和高级分析来开发预测模型，以完善个性化治疗策略并评估RT与药物的比较效果。
方法：在PubMed上进行了文献检索。使用AMSTAR-2工具评估荟萃分析的质量。
结果：纳入7项meta分析。一项荟萃分析报告，与对照组相比，RT后HO发生率显着降低。比较RT和非甾体抗炎药，一项和两项荟萃分析显示，RT在预防重度HO方面的疗效明显更高，在接受药物治疗的患者中效果更好，分别。关于RT设置，术后和术前RT均得到一项荟萃分析的支持.此外，两项荟萃分析显示，多级RT优于单级RT。荟萃分析的总体置信度是中等的，低,在一个人中非常低，三,和三个荟萃分析，分别。
结论：RT是一种经证实的HO预防性干预措施。然而,定时的精确优化，剂量,分馏需要阐明。未来的研究应侧重于通过大规模数据收集和高级分析来开发预测模型，以完善个性化治疗策略并评估RT与药物的比较效果。
