在哺乳动物物种中,怀孕是一个复杂的过程,涉及孕妇对怀孕的认识,植入,判定化,胎盘,和分娩。先天免疫系统由细胞成分组成,比如自然杀伤细胞,中性粒细胞,单核细胞,和巨噬细胞,和效应分子,如细胞因子,干扰素,抗菌肽,和补充成分。先天性免疫系统作为抵抗感染或炎症的第一道防线,在维持体内平衡和激活适应性免疫中起着至关重要的作用。在怀孕期间,先天性免疫细胞和效应分子作用于调节宿主防御和胚胎发育等过程的先天性免疫,植入,和母体-概念界面的胎盘。在这次审查中,我们描述了先天免疫系统的组成部分及其在母体-概念界面上的功能,以建立和维持形成血液或上皮视类型胎盘的动物物种的妊娠,包括人类,啮齿动物,反刍动物,和猪。
In mammalian species, pregnancy is a complex process that involves the maternal recognition of pregnancy, implantation, decidualization, placentation, and parturition. The innate immune system is composed of cellular components, such as natural killer cells, neutrophils, monocytes, and macrophages, and effector molecules, such as cytokines, interferons, antimicrobial peptides, and complement components. The innate immune system plays a critical role as the first line of defense against infection or inflammation to maintain homeostasis and activate the adaptive immunity. During pregnancy, innate immune cells and effector molecules act on the regulation of innate immunity for host defense and processes such as embryo development, implantation, and placentation at the maternal-conceptus interface. In this review, we describe the components of the innate immune system and their functions at the maternal-conceptus interface to establish and maintain pregnancy in animal species that form hemochorial- or epitheliochorial-type placentas, including humans, rodents, ruminants, and pigs.