PDF(Pubmed)
Abstract：
Atherosclerotic vascular disease disproportionately affects persons living with HIV (PLWH) compared to those without. The reasons for the excess risk include dysregulated immune response and inflammation related to HIV infection itself, comorbid conditions, and co-infections. Here, we review an updated understanding of immune and inflammatory pathways underlying atherosclerosis in PLWH, including effects of viral products, soluble mediators and chemokines, innate and adaptive immune cells, and important co-infections. We also present potential therapeutic targets which may reduce cardiovascular risk in PLWH.
摘要：
与没有艾滋病毒的人相比，动脉粥样硬化血管疾病不成比例地影响艾滋病毒感染者（PLWH）。过度风险的原因包括与HIV感染本身相关的免疫反应失调和炎症。合并症条件，和共同感染。这里,我们回顾了对PLWH动脉粥样硬化的免疫和炎症途径的最新认识，包括病毒产品的影响，可溶性介质和趋化因子，先天和适应性免疫细胞，和重要的共同感染。我们还提出了可能降低PLWH心血管风险的潜在治疗靶点。
