简介冠状病毒病(COVID-19)大流行给整个地球带来了高昂的成本。宿主之间复杂的相互作用,病毒,和环境导致了各种临床结果。了解疾病的严重程度和结果预测因素以提供早期预防措施以获得更好的结果至关重要。本研究旨在确定重症监护病房患者的临床和炎症特征与COVID-19感染结果的关系。方法采用逆转录聚合酶链反应(RTPCR)阳性检测方法,对入住重症监护病房的COVID-19患者进行回顾性研究。共有125名18岁以上的患者被纳入研究。病人的年龄,性别,和2型糖尿病等合并症,高血压,呼吸道疾病,并注意到冠状动脉疾病。病人的症状,生命体征,氧饱和度(Spo2),需要同向异构体,观察无创正压呼吸机支持(NIPPV)。入院时注意到计算机断层扫描严重程度评分(CTSS)以及血液学和炎症参数。记录患者作为幸存者和非幸存者的管理和治疗结果。结果非幸存者的平均年龄明显更大。常见的症状是发烧,呼吸窘迫,咳嗽,肌肉疼痛,喉咙痛.白细胞计数,C反应蛋白(CRP),尿素,肌酐,白细胞介素-6(IL-6),乳酸脱氢酶(LDH)更高,非幸存者组的血小板计数显著降低.在多变量逻辑回归中,CT严重程度评分,NIPPV,和IL-6的比值比分别为1.17,0.052和1.03.IL-6的敏感性为81.5%,特异性为81.8%,临界值为37.5。结论注意监测白细胞计数,CRP,尿素,肌酐,IL-6,LDH,血小板计数,CT严重程度评分对于管理COVID-19感染至关重要。在我们的研究中发现IL-6是作为结果预测因子的重要标志物。
Introduction The coronavirus disease (COVID-19) pandemic has incurred high costs for the entire planet. The complex interactions between the host, virus, and environment have resulted in various clinical outcomes. It is crucial to comprehend sickness severity and outcome predictors to provide early preventative measures for a better outcome. The current study aimed to determine the association of clinical and inflammatory profiles with the outcome of COVID-19 infection in patients admitted to the intensive care unit. Methods This retrospective study was done in patients admitted to intensive care units for COVID-19 with a positive reverse transcriptase polymerase chain reaction (RTPCR) assay. A total of 125 patients above 18 years were included in the study. The patient\'s age, gender, and co-morbidities like type 2 diabetes mellitus, hypertension, respiratory illness, and coronary artery disease were noted. The patient\'s symptomatology, vital signs, oxygen saturation (Spo2), need for inotropes, and non-invasive positive pressure ventilator support (NIPPV) were observed. Computed tomography severity score (CTSS) and hematological and inflammatory parameters at the time of admission were noticed. Patient\'s management and treatment outcomes as survivors and non-survivors were noted. Results The mean age was significantly greater in non-survivors. The common symptoms were fever, respiratory distress, cough, muscle pain, and sore throat. The leucocyte count, C-reactive protein (CRP), urea, creatinine, interleukin-6 (IL-6), and lactate dehydrogenase (LDH) were greater, and platelet counts were lower significantly in the non-survivors group. On multivariable logistic regression, CT severity score, NIPPV, and IL-6 had an odds ratio of 1.17, 0.052, and 1.03, respectively. IL-6 had a sensitivity of 81.5% and a specificity of 81.8% with a cut-off value of 37.5. Conclusion Vigilant monitoring of leucocyte count, CRP, urea, creatinine, IL-6, LDH, platelet count, and CT severity score is essential for managing COVID-19 infection. IL-6 was found to be a significant marker as a predictor of outcome in our study.