■血液肿瘤(HNs)是全球范围内第一种也是最常见的儿童癌症。目前,在西班牙儿科人群中,缺乏关于这些癌症发病率的最新人群数据.本研究旨在使用西班牙癌症登记网络的数据描述西班牙儿童(0-14岁)HN的发病率和发病率趋势,并将结果与其他南欧国家进行比较。
■数据来自1983年至2018年之间的15个西班牙人群癌症登记处。病例根据国际肿瘤疾病分类进行编码,第三版,第一次修订,并根据国际儿童癌症分类进行分组,第三版。原油利率(CR),特定年龄的比率,使用2013年欧洲人口(ASRE)计算和年龄标准化的发病率,并表示为每1,000,000儿童年的病例。估计了发病率趋势和年度百分比变化(APC)。
■总共记录了4,747个HN(59.5%的男孩)。年龄分布[n(%)]如下:<1岁,266(5.6%);1-4年,1,726(36.4%);5-9年,1,442(30.4%);10-14年,1313(27.6%)。白血病是最常见的群体,CR和ASRE为44.0(95CI:42.5;45.5)和44.1(95CI:42.6;45.7),分别。淋巴瘤的CR和ASRE分别为20.1(95CI:19.1;21.1)和20.0(95CI:19.0;21.1),分别。我们的结果与其他南欧国家的淋巴瘤发病率相似,虽然观察到白血病的一些差异。从1988年到2016年,男女白血病发病率趋势稳定。APC为0.0(95CI:-0.5;0.7),而在两个性别中,观察到淋巴瘤的总体持续增加,APC为1.0(95CI:0.4;1.6)。
■白血病是儿童中最常见的HN,自1988年以来,它们的发病率一直保持稳定,而淋巴瘤的发病率每年都在增加。淋巴瘤的发病率与其他南欧国家一样,而白血病的发病率仅与欧洲西南部国家相似。合作癌症登记项目允许评估癌症的流行病学指标,如HNs,这有助于卫生当局和临床医生提供更多关于这些恶性肿瘤的知识。
UNASSIGNED: Hematological neoplasms (HNs) are the first and most common childhood cancers globally. Currently, there is a lack of updated population-based data on the incidence of these cancers in the Spanish pediatric population. This study aimed to describe the incidence and incidence trends of HNs in children (0-14 years) in Spain using data from the Spanish Network of Cancer Registries and to compare the results with other southern European countries.
UNASSIGNED: Data were extracted from 15 Spanish population-based cancer registries between 1983 and 2018. Cases were coded according to the International Classification of Diseases for Oncology, third edition, first revision, and grouped according to the International Classification of Childhood Cancer, third edition. Crude rates (CRs), age-specific rates, and age-standardized incidence rates using the 2013 European population (ASRE) were calculated and expressed as cases per 1,000,000 child-years. Incidence trends and annual percentage changes (APCs) were estimated.
UNASSIGNED: A total of 4,747 HNs were recorded (59.5% boys). Age distribution [n (%)] was as follows: <1 year, 266 (5.6%); 1-4 years, 1,726 (36.4%); 5-9 years, 1,442 (30.4%); and 10-14 years, 1,313 (27.6%). Leukemias were the most common group, with a CR and an ASRE of 44.0 (95%CI: 42.5; 45.5) and 44.1 (95%CI: 42.6; 45.7), respectively. The CR and ASRE of lymphomas were 20.1 (95%CI: 19.1; 21.1) and 20.0 (95%CI: 19.0; 21.1), respectively. The comparable incidence rates between our results and those of other southern European countries were similar for lymphomas, while some differences were observed for leukemias. From 1988 to 2016, the trend in leukemia incidence was stable for both sexes, with an APC of 0.0 (95%CI: -0.5; 0.7), whereas a constant overall increase was observed for lymphoma in both sexes, with an APC of 1.0 (95%CI: 0.4; 1.6).
UNASSIGNED: Leukemias are the most common HNs in children, and their incidence has remained stable since 1988, whereas the incidence of lymphomas has increased every year. Lymphoma incidence is like that of other southern European countries, while leukemia incidence is similar only to that of southwestern European countries. Collaborative cancer registry projects allow for assessing epidemiological indicators for cancers such as HNs, which helps health authorities and clinicians provide more knowledge about these malignancies.