Abstract：
Testicular cancer (TCa) is a rare malignancy affecting young men worldwide. Sociodemographic factors, especially socioeconomic level (SEL) and healthcare access, seem to impact TCa incidence and outcomes, particularly among Hispanic populations. However, limited research has explored these variables in Hispanic groups. This study aimed to investigate sociodemographic and clinical factors in Mexico and their role in health disparities among Hispanic TCa patients. We retrospectively analyzed 244 Mexican TCa cases between 2007 and 2020 of a representative cohort with diverse social backgrounds from a national reference cancer center. Logistic regression identified risk factors for fatality: non-seminoma histology, advanced stage, and lower education levels. Age showed a significant trend as a risk factor. Patient delay and healthcare distance lacked significant associations. Inadequate treatment response and chemotherapy resistance were more likely in advanced stages, while higher education positively impacted treatment response. Cox regression highlighted non-seminoma histology, below-median SEL, higher education, and advanced-stage survival rates. Survival disparities emerged based on tumor histology and patient SEL. This research underscores the importance of comprehensive approaches that integrate sociodemographic, biological, and environmental factors to address health disparities improving outcomes through personalized interventions in Hispanic individuals with TCa.
摘要：
睾丸癌（TCA）是一种罕见的恶性肿瘤，影响全球年轻男性。社会人口因素，特别是社会经济水平(SEL)和医疗保健准入，似乎影响TCA的发生率和结果，特别是在西班牙裔人群中。然而,有限的研究在西班牙裔人群中探索了这些变量。这项研究旨在调查墨西哥的社会人口统计学和临床因素及其在西班牙裔TCA患者健康差异中的作用。我们回顾性分析了2007年至2020年间来自国家参考癌症中心的具有不同社会背景的代表性队列的244例墨西哥TCA病例。Logistic回归确定死亡的危险因素：非精原细胞瘤组织学，高级阶段,和较低的教育水平。年龄作为危险因素表现出显著趋势。患者延误和医疗距离缺乏显著关联。在晚期，治疗反应不足和化疗耐药的可能性更大。而高等教育对治疗反应有积极影响。Cox回归突出非精原细胞瘤组织学，低于中位数的SEL，高等教育,和晚期生存率。基于肿瘤组织学和患者SEL出现生存差异。这项研究强调了整合社会人口统计学、生物，和环境因素来解决健康差异，通过个性化干预改善西班牙裔TCA患者的结局。
