中国是世界上唯一没有将b型流感嗜血杆菌(Hib)疫苗纳入国家免疫规划的国家,这使得通过Hib疫苗接种来消除Hib相关疾病变得更加困难。有必要研究父母对Hib疫苗接种的偏好,以优化中国的疫苗推广策略。
本研究旨在调查中国父母对Hib疫苗接种的五个属性的偏好,即,原产地,有效性,不良事件,医生的建议,以及在决定为2岁以下的孩子接种疫苗时接种疫苗的价格。
于2020年11月至12月在浙江省两个城市进行了横断面调查,采用离散选择实验(DCE)。使用混合logit模型来估计参与父母对DCE中包括的Hib疫苗接种属性的偏好。还进行了亚组分析和概率分析,以捕获父母对Hib疫苗接种的偏好的异质性和权衡。
来自6,168个观察的数据包括在分析中。孩子的父母是,平均而言,更有可能表达对Hib疫苗接种的积极偏好。Hib疫苗接种的有效性和医生的建议等属性对父母对Hib疫苗接种的偏好有显著的积极影响,虽然进口疫苗,不良事件,和全面接种疫苗的价格对父母的偏好有显著的负面影响。具有不同人口统计学特征的父母也存在偏好Hib疫苗接种的异质性。如果Hib疫苗在有效性和安全性方面具有良好的表现,父母将在价格上进行权衡。
研究发现,不管Hib疫苗的来源地,如果疫苗具有更好的有效性和安全性,则有2岁以下儿童的父母更愿意在价格上妥协。医生的积极建议将增强他们对Hib疫苗接种的意愿。这些发现有助于在中国制定与父母进行Hib疫苗接种的沟通策略。
China is the only country in the world that has not included the Haemophilus influenzae type b (Hib) vaccine in its National Immunization Program, making it more difficult to eliminate Hib-related diseases through Hib vaccination. It is necessary to study parental preferences for Hib vaccination to optimize vaccine promotion strategies in China.
This study aimed to investigate Chinese parental preference for five attributes of Hib vaccination, i.e., the place of origin, effectiveness, adverse event, doctors\' recommendation, and the price of full vaccination when making a decision to vaccinate their children under 2 years old.
A cross-sectional survey was conducted in two cities in Zhejiang Province from November to December in 2020 using a discrete choice experiment (DCE). A mixed logit model was used to estimate participating parents\' preference for Hib vaccination attributes included in the DCE. Subgroup analysis and probability analysis were also conducted to capture the heterogeneity and trade-off of parental preference for Hib vaccination.
Data from 6,168 observations were included in the analyses. Parents of children are, on average, more likely to voice a positive preference for Hib vaccination. Such attributes of Hib vaccination as effectiveness and doctor\'s recommendation have a significant positive influence on parents\' preference for Hib vaccination, while imported vaccines, adverse events, and the price of full vaccination have a significant negative influence on parents\' preference. Parents with different demographic characteristics also existed heterogeneities in preference for Hib vaccination. Parents will make a trade-off on price if the Hib vaccine has a good performance on effectiveness and safety.
The study found that, regardless of the place of origin of the Hib vaccine, parents with children under 2 years old prefer to compromise on price if the vaccine has a better effectiveness and safety profile. A proactive recommendation from doctors would strengthen their willingness for Hib vaccination. These findings help aid the development of communication strategies with parents for Hib vaccination in China.