目的:探讨结膜下注射富血小板纤维蛋白(i-PRF)对自体结膜移植翼状胬肉术后愈合及并发症发生率的影响。
方法:这项回顾性和比较研究评估了在翼状胬肉手术后在供体和移植物结膜下注射i-PRF的31只眼,而34只眼在翼状胬肉手术后未接受i-PRF。患者随访期为12个月。术后复发,上皮愈合时间,术后疼痛评分,移植物水肿,和移植物的滑动(需要重新缝合)数据进行了评估。
结果:术后12个月,i-PRF组的一只眼(3.2%)出现角膜复发,非i-PRF组5只眼(14.7%)复发。平均角膜上皮愈合时间i-PRF组为2.96±0.70天,非i-PRF组为3.58±0.70天(p=0.001)。i-PRF组供体结膜上皮平均愈合时间为3.84±0.70天,而非i-PRF组为4.44±0.74天(p=0.006)。i-PRF组术后平均疼痛评分为4.45±1.52,非i-PRF组为5.08±1.40。在非i-PRF组中,三例(8.8%)需要重新缝合,然而,在i-PRF组中,没有人需要重新缝合。
结论:由于其血小板衍生的生长因子,i-PRF可以是一种安全有效的辅助疗法,可加快自体结膜移植物的愈合和预防复发。
OBJECTIVE: To investigate the effects of subconjunctival injectable platelet-rich fibrin (i-PRF) injection on healing and complication rates after pterygium surgery with conjunctival autograft.
METHODS: This retrospective and comparative study evaluated 31 eyes that received i-PRF injections under the donor and graft conjunctiva following pterygium surgery, while 34 eyes did not receive i-PRF after the pterygium surgery. The patients\' follow-up period was for 12 months. Postoperative recurrence, epithelial healing time, postoperative pain score, graft edema, and sliding of the graft (need for re-suturation) data were evaluated.
RESULTS: For the 12 months after surgery, one eye (3.2%) in the i-PRF group had developed corneal recurrence, and five eyes (14.7%) in the non-i-PRF group had developed recurrence. The mean corneal epithelial healing time was 2.96 ± 0.70 days in the i-PRF group and 3.58 ± 0.70 days in the non-i-PRF group (p = 0.001). The mean healing time of the donor conjunctiva epithelium was 3.84 ± 0.70 days in the i-PRF group, whereas it was 4.44 ± 0.74 days in the non-i-PRF group (p = 0.006). The mean postoperative pain score was 4.45 ± 1.52 in the i-PRF group and 5.08 ± 1.40 in the non-i-PRF group. In the non-i-PRF group, three cases (8.8%) required re-suturation, whereas, in the i-PRF group, no one required re-suturation.
CONCLUSIONS: Thanks to its platelets-derived growth factors, i-PRF can be a safe and effective adjuvant therapy for faster healing of conjunctival autograft and in the prevention of recurrence.