简介:镁是一种重要的细胞内阳离子,对于与能量代谢相关的320多个酶促反应至关重要,肌肉骨骼功能,和核酸合成,在人体生理中起着举足轻重的作用。本研究旨在探讨糖尿病患者血镁异常的患病率及其与血糖控制的相关性。药物使用,和糖尿病并发症。方法:在苏丹卡布斯大学医院进行了一项横断面研究,包括316名18岁或以上的糖尿病患者。数据包括人口统计,病史,药物,和生化参数。测定血清总镁浓度,镁血症定义为镁≤0.69mmol/L的低镁血症和≥1.01mmol/L的高镁血症。结果:糖尿病患者的低镁血症患病率为17.1%(95%CI:13.3-21.7%),高镁血症为4.1%(95%CI:2.4-7.0%)。女性在低镁血症组中的比例明显过高,高镁血症组高血压患病率较高,视网膜病变,白蛋白/肌酐比率增加,慢性肾脏病(CKD),肌酐水平升高,和较低的调节钙浓度。多因素logistic回归显示,女性和较高的血清调整钙是低镁血症的独立危险因素。相比之下,高血压的存在,更高水平的白蛋白/肌酐比率,5期CKD是高镁血症的独立危险因素。结论:低镁血症在糖尿病患者中很常见;然而,高镁血症与微血管并发症相关。
Introduction: Magnesium is a vital intracellular cation crucial for over 320 enzymatic reactions related to energy metabolism, musculoskeletal function, and nucleic acid synthesis and plays a pivotal role in human physiology. This study aimed to explore the prevalence of dysmagnesemia in patients with diabetes mellitus and evaluate its correlations with glycemic control, medication use, and diabetic complications. Methods: A cross-sectional study was conducted at Sultan Qaboos University Hospital, including 316 patients aged 18 years or older with diabetes mellitus. Data included demographics, medical history, medications, and biochemical parameters. Serum total magnesium concentrations were measured, and dysmagnesemia was defined as magnesium ≤ 0.69 mmol/L for hypomagnesemia and ≥1.01 mmol/L for
hypermagnesemia. Results: The prevalence of hypomagnesemia in patients with diabetes was 17.1% (95% CI: 13.3-21.7%), and
hypermagnesemia was 4.1% (95% CI: 2.4-7.0%). Females were significantly overrepresented in the hypomagnesemia group, while the
hypermagnesemia group showed a higher prevalence of hypertension, retinopathy, an increased albumin/creatinine ratio, chronic kidney disease (CKD), elevated creatinine levels, and a lower adjusted calcium concentration. The multinominal logistic regression exhibited that the female sex and higher serum-adjusted calcium were independent risk factors of hypomagnesemia. In contrast, the presence of hypertension, higher levels of albumin/creatinine ratio, and stage 5 CKD were independent risk factors of
hypermagnesemia. Conclusions: Hypomagnesemia was common among patients with diabetes mellitus; however,
hypermagnesemia was associated with microvascular complications.