Abstract：
According to epidemiological studies, constipation has a negative effect on life expectancy, necessitating appropriate treatment. According to the Pharmaceuticals and Medical Devices Agency (PMDA), patients who have been taking magnesium oxide (MgO) for constipation over a prolonged period, especially those with impaired renal function and older individuals, are at high risk of hypermagnesemia. Therefore, serum Mg levels, which are often not checked in clinical practice, should be monitored in these patients. Thus, to predict elevated serum Mg levels and prevent the development of hypermagnesemia, we aimed to identify the risk factors of hypermagnesemia, especially in the older population. Our study included patients who were prescribed MgO at our hospital between January 1, 2014, and March 31, 2016. Patients who did not meet the inclusion criteria were excluded and matched to adjust for background factors; finally, 35 patients in the hypermagnesemia arm and 140 patients in the non-hypermagnesemia arm were included in the analysis. Multivariate analysis identified estimated creatinine clearance (eCcr) ≤ 28.2 mL/min as a statistically significant risk factor. In addition, MgO dose ≥ 900 mg/day was identified as a risk factor for clinical consideration, although not statistically significant. Furthermore, the incidence of hypermagnesemia was shown to increase to 11.6% for those with MgO dose ≥ 900 mg/day, 27.0% for those with eCcr ≤ 28.2 mL/min, and 53.1% for those with both. Hypermagnesemia may occur in older patients with eCcr ≤ 28.2 mL/min who take more than 900 mg/day of MgO.
摘要：
根据流行病学研究,便秘对预期寿命有负面影响，需要适当的治疗。根据药品和医疗器械局（PMDA），长期服用氧化镁（MgO）治疗便秘的患者，尤其是那些肾功能受损的人和老年人，高镁血症的风险很高.因此,血清镁水平，在临床实践中通常不检查，应该对这些患者进行监测。因此，预测血清Mg水平升高并预防高镁血症的发展，我们的目的是确定高镁血症的危险因素，尤其是老年人口。我们的研究包括2014年1月1日至2016年3月31日在我们医院接受MgO治疗的患者。不符合纳入标准的患者被排除并匹配以调整背景因素；最后，分析包括高镁血症组的35例患者和非高镁血症组的140例患者。多变量分析确定肌酐清除率（eCcr）≤28.2mL/min为统计学上有意义的危险因素。此外,MgO剂量≥900毫克/天被确定为临床考虑的风险因素，虽然没有统计学意义。此外，MgO剂量≥900mg/天的患者高镁血症的发生率增加至11.6％，eCcr≤28.2mL/min的为27.0%，两者都有53.1%。高镁血症可能发生在eCcr≤28.2mL/min的老年患者，服用超过900mg/天的MgO。
