目的:尽管感染性病原体是诱发和维持免疫系统紊乱的主要因素,很少有报道证实幽门螺杆菌(H.幽门螺杆菌)感染和干燥综合征。本研究旨在证明干燥综合征与幽门螺杆菌感染之间的相关性。突出各种临床特征和危险因素。
方法:对2012年1月1日至2021年2月10日在温州医科大学附属第一医院(温州,中国)。所有招募的干燥综合征和幽门螺杆菌感染受试者仅通过在线验证可用的医疗记录纳入。
结果:在这项研究中,从2012年1月1日至2021年2月10日,共有224例患者被诊断为干燥综合征。其中,干燥综合征患者94例(41.96%)感染幽门螺杆菌。因此,临床表现,血清学和免疫学特征,报告了纳入的原发性干燥综合征(pSS)患者的胃镜活检结果.感染幽门螺杆菌的干燥综合征患者的多变量分析显示高丙种球蛋白血症(比值比[OR],0.354;95%置信区间[CI],0.189-0.663),总胆固醇(或,1.158;95%CI,0.856-1.550),高血压(OR,0.227;95%CI,0.114-0.455),女性性别(或,5.778;95%CI,1.458-22.9),抗SSA/Ro60阳性(或,2.384;95%CI,233-4.645),γ-GT(OR,0.99;95%CI,0.99-1.00)和碱性磷酸酶(ALP,OR,1.00;95%CI,0.99-1.00)水平。
结论:一起,我们的研究结果表明,高丙种球蛋白血症可能是干燥综合征患者幽门螺杆菌感染的独立危险因素,将来需要医生的建议。
Although infectious pathogens are predominant factors for inducing and maintaining immune system disorders, there exist few reports establishing the significant correlation between Helicobacter pylori (H. pylori) infection and Sjogren\'s syndrome. This study aims to demonstrate the correlation between Sjogren\'s syndrome and H. pylori infection in patients, highlighting various clinical characteristics and risk factors.
A single-center retrospective observational study was conducted in patients (n = 224) admitted from January 1, 2012, to February 10, 2021, in the First Affiliated Hospital of Wenzhou Medical University (Wenzhou, China). All the recruited subjects with Sjogren\'s syndrome and H. pylori infection were only included by validating the available medical records online.
In this study, a total of 224 patients from January 1, 2012, to February 10, 2021, were diagnosed with Sjogren\'s syndrome. Among them, 94 patients (41.96%) with Sjogren\'s syndrome were infected with H. pylori. Accordingly, the clinical manifestations, serological and immunological characteristics, as well as gastroscopic biopsy outcomes of the recruited patients with primary Sjogren\'s syndrome (pSS) were reported. The multivariable analysis of the dry syndrome patients infected with H. pylori displayed
hypergammaglobulinemia (odds ratio [OR], 0.354; 95% confidence interval [CI], 0.189-0.663), total cholesterol (OR, 1.158; 95% CI, 0.856-1.550), hypertension (OR, 0.227; 95% CI, 0.114-0.455), Female sex (OR, 5.778; 95% CI, 1.458-22.9), anti-SSA/Ro60 positive (OR, 2.384; 95% CI, 233-4.645), γ-GT (OR, 0.99; 95% CI, 0.99-1.00) and alkaline phosphatase (ALP, OR, 1.00; 95% CI, 0.99-1.00) levels.
Together, our findings demonstrated that
hypergammaglobulinemia could be the independent risk factors of H. pylori infection in patients with Sjogren\'s syndrome, requiring the physician\'s advice in the future.