Abstract：
UNASSIGNED: Angioimmunoblastic T-cell lymphoma (AITL), a subtype of peripheral T-cell lymphoma (PTCL), is associated with unique clinical, morphological, and immunohistochemical features. The peripheral circulation might show presence of an occasional reactive plasma cell but significant plasmacytosis masquerading as plasma cell leukemia is rare. We report a case of AITL in a 42-year-old male, who presented with two-month history of generalized lymphadenopathy. On investigations, he had hypergammaglobulinemia and plasmacytosis in the peripheral blood and bone marrow masquerading as plasma cell leukemia. Immunohistochemistry and serum protein electrophoresis revealed polyclonal nature of plasma cells. Diagnosis of AITL was made on cervical lymph node biopsy. This case highlights the diagnostic challenge faced due to heterogeneity in the clinical presentation and pathological findings and to alert the clinician so that timely accurate diagnosis can be made to initiate the treatment.
摘要：
■血管免疫母细胞性T细胞淋巴瘤（AITL），外周T细胞淋巴瘤（PTCL）的一种亚型，与独特的临床相关，形态学,和免疫组织化学特征。外周循环可能显示偶尔存在反应性浆细胞，但由于浆细胞白血病而伪装的大量浆细胞增多很少。我们报告了一例AITL患者为一名42岁男性，有两个月的全身淋巴结病病史。关于调查，他的外周血和骨髓中有高丙种球蛋白血症和浆细胞增多症，伪装成浆细胞白血病。免疫组织化学和血清蛋白电泳显示浆细胞的多克隆性质。AITL的诊断是通过颈淋巴结活检得出的。该病例突出了由于临床表现和病理发现的异质性而面临的诊断挑战，并提醒临床医生，以便及时做出准确的诊断以开始治疗。
