透明质酸和氨基酸在伤口愈合过程中起着重要作用,刺激结缔组织的发育和成纤维细胞的活性和增殖。本对照临床研究的目的是根据伤口闭合率评估含有透明质酸和氨基酸的局部凝胶配方的临床疗效,止痛药的摄入量,患者报告疼痛和水肿。
这项研究包括需要单颗拔牙的患者。患者被随机分为两组,采用不同的术后护理方案。试验组患者使用基于氨基酸和透明质酸的凝胶,而对照组不使用任何产品。在不同的时间点测量两组的每个参数:手术后立即,7、14、30和60天后。
共有40名患者(46.52±9.84岁)完成了观察期,并检查了40个提取插座。7天后,试验组水肿明显较低。测试组中报告的疼痛较低,没有显着差异,除了7天的第一个时间点。有了后续调查问卷,宣布主要在手术后的前7天服用止痛药的患者;然而,试验组对止痛药的需求低于对照组。
术后和家庭使用基于氨基酸和透明质酸的凝胶来管理拔牙后的软组织闭合是减少肿胀的有效辅助手段,疼痛,需要止痛药.需要更多的研究来支持本研究的结果。
Hyaluronic acid and amino acids play an important role in the wound healing process, stimulating the development of the connective tissue and the activity and proliferation of fibroblasts. The aim of the present controlled clinical study was to evaluate the clinical efficacy of a topical gel formula containing hyaluronic acid and amino acids in terms of wound closure rate, painkiller intake, and patients\' reported pain and edema.
This study included patients in need of a single tooth extraction. Patients were randomized into two groups with differing post-operative care regimens. Patients in the test group used the amino acid and hyaluronic acid-based gel, while the control group did not use any product. Each parameter was measured in both groups at different time points: immediately after surgery, and after 7, 14, 30, and 60 days.
A total of 40 patients (46.52 ± 9.84 years old) completed the observational period, and 40 extraction sockets were examined. After 7 days, the edema was significantly lower in the test group. The reported pain was lower in the test group without a significant difference, except for the first time point at 7 days. With the follow-up questionnaire, patients declared to have taken painkillers mainly during the first 7 days after surgery; however, the test group showed a lower need for painkillers than the control group.
The post-operative and domiciliary use of an amino acid and hyaluronic acid-based gel for the management of soft tissue closure after tooth extraction is a valid coadjutant to reduce swelling, pain, and the need for painkillers. Additional studies are required to support the results of the present study.