PDF(Pubmed)
Abstract：
The purpose of this scoping review was to identify possible chondrotoxic effects caused by drugs usually used for intra-articular injections. PubMed, Scopus, Web of Science and Cochrane were searched. Inclusion criteria required randomized controlled trials written in English that evaluate the toxic effect that damages the cartilage. The literature search resulted in 185 unique articles. 133 full-text articles were screened for inclusion, of which 65 were included. Corticosteroids, with the exception of triamcinolone, along with local anaesthetics, potentially excluding ropivacaine and liposomal bupivacaine, and nonsteroidal anti-inflammatory drugs, exhibited insufficient safety profiles to warrant casual use in clinical settings. Hyaluronic acid, on the other hand, appears to demonstrate safety while also mitigating risks associated with concurrent compounds, thereby facilitating therapeutic combinations. Additionally, there remains a paucity of data regarding platelet-rich plasma, necessitating further evaluation of its potential efficacy and safety. Overall, it seems that results are significantly influenced by the dosage and frequency of injections administered, observed in both human and animal studies.
摘要：
这项范围审查的目的是确定通常用于关节内注射的药物可能引起的软骨毒性作用。PubMed,Scopus,搜索了WebofScience和Cochrane。纳入标准需要用英语撰写的随机对照试验来评估损伤软骨的毒性作用。文献检索产生了185篇独特的文章。筛选了133篇全文供收录，其中包括65个。皮质类固醇,除了曲安奈德,除了局部麻醉剂，可能排除罗哌卡因和脂质体布比卡因，和非甾体抗炎药，表现出的安全性不足，无法保证在临床环境中随意使用。透明质酸,另一方面,似乎证明了安全性，同时也减轻了与并发化合物相关的风险，从而促进治疗组合。此外,关于富血小板血浆的数据仍然很少，需要进一步评估其潜在的疗效和安全性。总的来说,结果似乎受到注射剂量和频率的显著影响，在人类和动物研究中观察到。
