婴儿非分泌型组织蛋白组抗原表型与症状性轮状病毒腹泻的风险降低相关，严重小儿腹泻病和死亡的主要全球原因之一。然而,关于分泌状态在无症状轮状病毒感染中的作用知之甚少。因此,我们在先前在达卡进行的出生队列研究中进行了嵌套病例对照研究，孟加拉国,为了确定婴儿分泌表型与无症状轮状病毒感染的几率之间的关联，除了轮状病毒腹泻的风险，未接种疫苗的婴儿。在父队列中，婴儿在出生后第一周入组,并在出生后的头两年随访,进行多次门诊就诊和腹泻病的积极监测.对唾液进行分泌因子表型分析。通过实时RT-PCR检测了生命第一年收集的11份监测粪便的轮状病毒，然后进行常规PCR和扩增子测序以鉴定阳性标本的感染P型。类似于症状性腹泻的发现，婴儿非分泌者在出生后第一年内经历的无症状轮状病毒感染原发发作明显较少,可能是轮状病毒P基因型依赖性.这些数据表明，非分泌者由于对感染的易感性降低而不是感染严重程度降低，因此轮状病毒的风险降低。
The infant non-secretor histoblood group antigen phenotype is associated with reduced risk of symptomatic rotavirus diarrhea, one of the leading global causes of severe pediatric diarrheal disease and mortality. However, little is known regarding the role of secretor status in asymptomatic rotavirus infections. Therefore, we performed a nested case-control study within a birth cohort study previously conducted in Dhaka, Bangladesh, to determine the association between infant secretor phenotype and the odds of asymptomatic rotavirus infection, in addition to the risk of rotavirus diarrhea, in unvaccinated infants. In the parent cohort, infants were enrolled in the first week of life and followed through the first two years of life with multiple clinic visits and active surveillance for diarrheal illness. Secretor phenotyping was performed on saliva. Eleven surveillance stools collected over the first year of life were tested for rotavirus by real-time RT-PCR, followed by conventional PCR and amplicon sequencing to identify the infecting P-type of positive specimens. Similar to findings for symptomatic diarrhea, infant non-secretors experienced significantly fewer primary episodes of asymptomatic rotavirus infection through the first year of life in a likely rotavirus P-genotype-dependent manner. These data suggest that non-secretors experienced reduced risk from rotavirus due to decreased susceptibility to infection rather than reduced infection severity.
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